203395-82-8 Usage
Description
2-Deschloro Aripiprazole, also known as Aripiprazole impurity B, is a derivative of the antipsychotic agent Aripiprazole (A771000). It is characterized by the absence of a chlorine atom at the 2nd position in its molecular structure. 2-Deschloro Aripiprazole is primarily recognized as an impurity associated with the production and formulation of Aripiprazole, which is a medication used for treating various psychiatric disorders.
Uses
Used in Pharmaceutical Industry:
2-Deschloro Aripiprazole is used as an impurity reference substance for the antipsychotic agent Aripiprazole (A771000). Its presence is crucial in the quality control and assurance processes to ensure the safety, efficacy, and purity of the final drug product. As an impurity, it helps in the development of analytical methods for the detection and quantification of related substances in Aripiprazole formulations.
Used in Research and Development:
In the field of pharmaceutical research and development, 2-Deschloro Aripiprazole serves as a valuable compound for studying the structure-activity relationship of Aripiprazole and its analogs. This understanding can lead to the design and synthesis of new antipsychotic agents with improved pharmacological properties and reduced side effects.
Used in Regulatory Compliance:
2-Deschloro Aripiprazole is used as a reference material in the regulatory processes related to the approval and monitoring of Aripiprazole-based medications. It aids in establishing the acceptable limits of impurities in the final drug product, thereby ensuring that the medication meets the required standards for quality and safety.
Check Digit Verification of cas no
The CAS Registry Mumber 203395-82-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,3,3,9 and 5 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 203395-82:
(8*2)+(7*0)+(6*3)+(5*3)+(4*9)+(3*5)+(2*8)+(1*2)=118
118 % 10 = 8
So 203395-82-8 is a valid CAS Registry Number.
203395-82-8Relevant articles and documents
Novel antipsychotic agents with dopamine autoreceptor agonist properties: Synthesis and pharmacology of 7-[4-(4-phenyl-1- piperazinyl)butoxy]-3,4-dihydro-2(1H)-quinolinone derivatives
Oshiro, Yasuo,Sato, Seiji,Kurahashi, Nobuyuki,Tanaka, Tatsuyoshi,Kikuchi, Tetsuro,Tottori, Katsura,Uwahodo, Yasufumi,Nishi, Takao
, p. 658 - 667 (2007/10/03)
To develop a novel antipsychotic agent which is an agonist of dopamine (DA) autoreceptors and an antagonist of postsynaptic DA receptors, a series of 7-[4-[4-(substituted phenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)- quinolinones was synthesized and their dual activities were examined. The postsynaptic DA receptor antagonistic activities of the compounds were evaluated by their ability to inhibit stereotypy induced by apomorphine in mice, and the autoreceptor agonist activities were determined by their effects on the γ-butyrolactone (GBL)-induced increase in L- dihydroxyphenylalanine (DOPA) synthesis in the mouse brain. Many compounds inhibited the stereotypic behavior, and several compounds reversed the GBL- induced increase in the DOPA synthesis. Among them, 7-[4-[4-(2,3- dichlorophenyl)-l-piperazinyl]butoxy]-3,4-dihydro-2(1H)-quinolinone (28, aripiprazole, OPC-14597) was found to have these two activities. This compound reversed the GBL-induced DOPA synthesis (ED50 values of 5.1 μmol/kg po) and inhibited the APO induced stereotypy (ED50 values of 0.6 μmol/kg po). Compound 28 induced catalepsy at 10 times higher dose than that required for the antagonism of APO-induced stereotypy (ED50 value of 7.8 μmol/kg po).
