203452-44-2

Upstream product

• 71535-50-7 (S)-(+)-2-benzyl-1-(p-tolylsulfonyl)aziridine 
• 128788-45-4 1-(3,3-Dimethoxy-butane-1-sulfonyl)-4-methyl-benzene 
• 203452-43-1 (2S,4S)-2-Benzyl-6-methyl-1,4-bis-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-pyridine 

Relevant academic research and scientific papers

1,4-Bis(arylsulfonyl)-1,2,3,4-tetrahydropyridines in synthesis. Intramolecular alkylation reactions and stereoselective synthesis of anti-2,6-disubstituted piperidines

1,4-Bis(arylsulfonyl)-1,2,3,4-tetrahydropyridines 1 having R1 containing aromatic groups undergo intramolecular electrophilic aromatic substitution reactions to give benzo-fused bicyclo[3.3.1] systems with chemoselectivities which depend on the nature of the acidic reagent used. Cationic hydrogenation of the C-5-C-6 double bond in substrates 1 substituted at C-6 provides an entry to anti-2,6-disubstituted piperidines upon desulfonylation.