20349-50-2Relevant academic research and scientific papers
Synthesis and antibacterial activity of 2-(2-(cyclopropylmethoxy) phenyl)-5-methyl-1,3,4- oxadiazole
Parameshwar,Selvam,Ghashang, Majid,Guhanathan
, p. 1502 - 1512 (2017/07/18)
Heterocyclic compounds containing the five-membered oxadiazole nucleus possess verity of biological activities. 1,3,4- oxadiazole moieties are important because of their versatile biological action. The present study depicts synthesis of some novel 2-(2-(cyclopropylmethoxy)phenyl)-5-methyl-1,3,4- oxadiazole was prepared from N’-acetyl-2-(cyclopropylmethoxy)benzohydrazide by using triphenylphosphine, triethylamine, carbon tetrachloride and acetonitrile at 100°C for 1h. The final compound was examined for its antibacterial activity.
Synthesis and Biological Evaluation of Some Heterocyclic Compounds from Salicylic Acid Hydrazide
Sarshira,Hamada,Moghazi,Abdelrahman
, p. 1970 - 1982 (2016/11/23)
Different heterocyclic compounds were prepared starting from 2-hydroxy benzohydrazide; for example, cyclization of hydrazide hydrazone 3 derived from 2-hydroxybenzohydrazide 2 with acetic anhydride or concentrated sulfuric acid gave 1,3,4-oxadiazole derivatives 4–5. On the other hand, direct cyclization of 2-hydroxy benzohydrazide 2 with one carbon cyclizing agent gave a new derivative of 1,3,4-oxadiazole 7, 8, 9, 10, 11. Heating of hydrazide hydrazone 3 with thioglycolic acid in pyridine gave thiazolidinone 12. When 2-hydroxy benzohydrazide 2 reacted with aliphatic carboxylic acids such as formic acid or acetic acid, it gave the corresponding N-formyl or N-acetyl derivatives 6. Subsequent cyclization of 6 using phosphorous pentasulphide in pyridine gave 1,3,4-thiadiazoles 13. Cyclization of 2-hydroxy benzohydrazide with ethyl acetoacetate gives pyrazolone derivative 14. Finally, when an ethanolic solution of acid hydrazide 2 was treated with ammonium thiocyanate in 35% HCl, it gave the thiosemicarbazide 15. Subsequent treatment of 15 with concentrated sulfuric acid or 10% sodium hydroxide gave 5-amino-1,3,4-thiadiazole 16 and 1,2,4-triazole 17, respectively. The structures of all newly isolated compounds were confirmed using1H NMR, IR spectra, and elemental analyses. The antimicrobial activities for all isolated compounds were examined against different microorganisms.
Four novel nanometer-sized cobalt azametallacrown complexes
Lin, Shen,Liu, Shi-Xiong,Huanga, Jian-Quan,Lina, Chi-Chang
, p. 1595 - 1601 (2007/10/03)
Four nanometer-sized cobalt azametallacrowns, [Co6(C8H6N3O3) 6(CH3OH)6]·10CH3OH ·2H2O (1), [Co6(C8H5N2O3) 6-(CH3OH)6]·5CH3OH ·0.5H2O (2), [Co6(C9H7N2O3) 6(CH3OH)6]·6CH3OH (3), and [Co6(C10H9N2O3) 6(CH3OH)6]·7CH3OH ·2H2O (4) have been synthesized by the self-assembly reaction of cobalt ions with N-substituted salicylhydrazide ligands. The cobalt atoms in the four azametallacrowns adopt a propeller configuration. The chiralities of the cobalt atoms alternate between the ∧ and Δ forms. In 1, there are two encapsulated methanol solvent molecules in the 'host' cavity of the azametallacrown molecule, whereas in 2-4 there are no guest molecules in the 'host' cavities of the azametallacrowns.
Excited state intramolecular proton transfer reaction and luminescent properties of the ortho-hydroxy derivatives of 2,5-diphenyl-1,3,4-oxadiazole
Doroshenko, Andrey O.,Posokhov, Eugene A.,Verezubova, Alla A.,Ptyagina, Lydia M.
, p. 253 - 265 (2007/10/03)
Luminescent properties of several ortho-hydroxy derivatives of 2,5-diphenyl-1,3,4-oxadiazole were studied in solvents of different polarity and protolytic ability and compared with the analogous derivatives of 1,3-oxazole, studied by us earlier. Evaluatio
