20359-31-3Relevant academic research and scientific papers
Synthesis of 1-Substituted Isoquinolines by Heterocyclization of TosMIC Derivatives: Total Synthesis of Cassiarin A
Gutiérrez, Sara,Coppola, Anna,Sucunza, David,Burgos, Carolina,Vaquero, Juan J.
, p. 3378 - 3381 (2016)
A new method for the synthesis of 1-substituted isoquinolines by a heterocyclization that involves α-benzyl TosMIC derivatives and different electrophiles has been developed. This methodology has been successfully applied to a total synthesis of cassiarin A, an alkaloid with potent antiplasmodial activity against Plasmodium falciparum.
