203636-24-2Relevant academic research and scientific papers
Chemoselective peptide bond formation using formyl-substituted nitrophenylthio ester
Ishiwata, Akihiro,Ichiyanagi, Tsuyoshi,Takatani, Maki,Ito, Yukishige
, p. 3187 - 3190 (2003)
A novel method for peptide bond formation utilizing amino acid 2-formyl-4-nitrophenylthio ester has been developed. The reaction can be performed in water-containing media and is compatible with various types of amino acid side-chain functional groups. Use of N-methylmaleinimide as an additive is essential for the reaction to proceed with high efficiency. It captures liberated formyl-substituted thiophenol through 1,4-addition followed by aldol cyclization.
Rapid and efficient synthesis of peptide fragments containing α- aminoisobutyric acid using Fmoc-amino acid chlorides/potassium salt of 1- hydroxybenzotriazole
Suresh Babu, Vommina V.,Gopi, Hosahudya N.
, p. 1049 - 1050 (2007/10/03)
The synthesis of peptides containing multiple Aib residues was accomplished using Fmoc-Aib-Cl in presence of KOBt. As no additional base was added, the duration of coupling reactions could be extended. Thus, the synthesis of the alamethicin 1-4 fragment, Aib-Pro-Aib-Ala, the emerimicin 2- 6 fragment, Aib-Aib-Aib-Val-Gly and the Aib tetramer, Fmoc-(Aib)4-OBzl were accomplished in good yield and purity.
