20364-70-9Relevant academic research and scientific papers
Cis-selective and highly enantioselective hydrogenation of 2,3,4-trisubstituted quinolines
Zhang, Zhenhua,Du, Haifeng
, p. 2816 - 2819 (2015)
A highly enantioselective cis-hydrogenation of 2,3,4-trisubstituted quinolines has been realized for the first time using chiral borane catalysts generated in situ from chiral dienes. A variety of tetrahydroquinoline derivatives containing three contiguous stereogenic centers were obtained in 76-99% yields with 82-99% ee's.
A 1, 2, 3, 4 - tetrahydroquinoline derivative and its preparation method (by machine translation)
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Paragraph 0065, (2017/08/02)
The invention discloses a 1, 2, 3, 4 - tetrahydroquinoline derivative and its preparation method. Type I shown compound preparation method, comprises the following steps: in the HB (C6 F5 )2 And under the catalysis of styrene, type II of a compound of hydrogen reduction reaction, can be obtained as shown in formula I compound. Having optical activity of formula I illustrated compound of preparation method, comprises the following steps: in the HB (C6 F5 )2 With the type III is shown under the catalysis of the compound of, the formula II compound with hydrogen as shown by the reduction reaction, to obtain optically active compounds of formula I as shown. The invention to HB (C6 F5 )2 With styrene as catalyst, in order to different structure of the quinoline derivatives as substrate, yield of synthetic all-cis - 1, 2, 3, 4 - tetrahydroquinoline derivatives, can control the stereo selectivity of the product; to HB (C6 F5 )2 With a chiral double the alkene is catalyst, in order to different structure of the quinoline derivatives as substrate, yield of synthesis of optically active 1, 2, 3, 4 - tetrahydroquinoline derivatives, can be control product of the enantioselectivity. (by machine translation)
