20368-12-1

Upstream product

• 111-86-4 n-Octylamine 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 1438396-01-0 C₁₈H₂₇NO₄ 
• 1438396-28-1 C₂₃H₃₁N₂O₃⁽¹⁺⁾*Br^(1-) 
• 1438396-25-8 C₂₄H₄₁N₂O₃⁽¹⁺⁾*Br^(1-) 
• 1438396-22-5 C₁₈H₂₆BrNO₃ 
• 1438396-16-7 C₂₃H₃₃N₂O₃⁽¹⁺⁾*Cl^(1-) 
• 1438396-13-4 C₂₄H₄₃N₂O₃⁽¹⁺⁾*Cl^(1-) 
• 1438396-09-8 C₁₈H₂₈ClNO₃ 
• 1438396-06-5 C₁₈H₂₉NO₄ 
• 101452-59-9 piperidino-acetic acid octylamide 

Relevant academic research and scientific papers

Diversity oriented synthesis of novel haloglycolipids potentially useful for crystallization of integral membrane proteins

A series of novel haloglycolipids were synthesized based on Cu(i) catalyzed Huisgen's [3 + 2] cycloaddition reaction of diversely functionalized azides and alkynes, using a mixture of N-bromosuccinimide and Cu(i) halide as the halogen source. Since halogen atoms, like bromine and iodine, with a very high scattering power facilitate the solving of crystal structures, the title haloglycolipids could prove to be invaluable in structure-based drug design involving membrane proteins as targets. This journal is the Partner Organisations 2014.

Reduction of Nicotinamides, Flavins, and Manganese Porphyrins by Formate, Catalyzed by Membrane-Bound Rhodium Complexes

Two polymerizable cyclopentadienyl-2,2'-bipyridinerhodium complexes and one amphiphilic rhodium complex have been synthesized and incorporated into the bilayers of vesicles formed from a polymerizable ammonium surfactant.Incorporation was achieved by chemical linkage (via a copolymerization reaction) or by physical absorption.The complexes are located at different positions in the bilayer, viz. in the hydrophobic interior or at the aqueous interface.The anchored rhodium complexes efficiently catalyze the reduction of both two-electron substrates (e.g., nicotinamides and flavin) and one-electron substrates (e.g., manganese(III) porphyrins) by sodium formate.Kinetic studies indicate that the rate-limiting step of the reaction is the reduction of the rhodium center by formate, leading to a rhodium(III) hydride or a rhodium(I) species.The three complexes showed different catalytic activities.Cyclic voltammetry and UV-vis measurements revealed that their reduction potentials ((2+) + 2e(-) ->/a values ((+) ->/- Rh(I) + H(+)) are also different.From the observed trends it is concluded that the catalytic activity of the rhodium complexes depends on its position in the bilayer.

Synthesis and properties of 1-(2-(alkylamino)-2-oxoethyl) pyridinium chloride surfactants

A series of 1-(2-(alkylamino)-2-oxoethyl) pyridinium chloride surfactants was designed and synthesised by two steps. Four new compounds were obtained. The structures of all the synthesised compounds have been characterised by IR, 1H NMR and elemental analyses. Surface activity and antibacterial activity of 1-(2-(alkylamino)-2-oxoethyl) pyridinium chloride surfactants were investigated. The critical micelle concentration and C20 values of the synthesised surfactants are low. The synthesised surfactants have good antibacterial activity for sulfate-reducing bacteria, metatrophic bacteria and iron bacteria in oil field injection water.

Benzothiazole derivative multifunctional lubricating oil additive, preparation method and application thereof

The invention discloses a benzothiazole derivative multifunctional lubricating oil additive, a preparation method and application thereof. The preparation method specifically includes: firstly subjecting alkylamine and chloroacetyl chloride to amidation reaction to obtain alkyl chloroacetamide, then reacting 2-mercaptobenzothiazole with carbon disulfide and alkyl chloroacetamide to obtain the benzothiazole derivative multifunctional lubricating oil additive with a structure shown as general formula I. The benzothiazole derivative multifunctional lubricating oil additive has the characteristicsof simple preparation method, mild process conditions, easily available raw material, low synthesis cost, high synthesis yield and the like, can be used as an extreme pressure, antiwear, antifrictionand corrosion resistant additive of lubricating oil, can obviously improve the bearing capacity of base oil and improve the wear resistance and antifriction performance, and is an environment-friendly multifunctional lubricating oil additive.

Pyrimidine derivative multifunctional lubricating oil additive as well as preparation method and application thereof

The invention discloses a pyrimidine derivative multifunctional lubricating oil additive as well as a preparation method and application thereof. The preparation method of the pyrimidine derivative multifunctional lubricating oil additive comprises the following steps: firstly, enabling alkylamine and chloroacetyl chloride to be subjected to amidation reaction to obtain alkyl chloroacetyl chloride; then taking 4,6-dimethyl-2-mercaptopyrimidine to react with carbon disulfide and the alkyl chloroacetyl chloride, so as to obtain the pyrimidine derivative multifunctional lubricating oil additive with a general formula I. The pyrimidine derivative multifunctional lubricating oil additive disclosed by the invention has the characteristics of simple preparation method, moderate technological conditions, easiness for obtaining raw materials, low synthesis cost, high synthesis yield and the like, and can be used as an extreme-pressure, wear-resisting, friction-reduction and anticorrosion additive of lubricating oil; the bearing capability of base oil can be remarkably improved and the wear-resisting and friction-reduction performance is improved, so that the pyrimidine derivative multifunctional lubricating oil additive is an environment-friendly multifunctional lubricating oil additive. The formula I is shown in the description.

Complexes of selected late period lanthanide(III) cations with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid amide (DOTAM)-alkyl ligands-A new platform for the development of paramagnetic chemical exchange saturation transfer (PARACEST) magnetic resonance imaging (MRI) contrast agents

A series of 18 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid amide (DOTAM)-alkyl derived complexes with selected late lanthanide(III) cations (Dy3+, Tb3+, and Tm3+) has been synthesized; their magnetic properties have been evaluated and compared to those derived from DOTAM. Peralkylation of cyclen with corresponding N-iodoacetyl amines was utilized as the key step in the synthesis. Chemical exchange saturation transfer (CEST) spectra of the complexes have been acquired at 37 C, revealing that Tm3+-derived DOTAM-alkyl complexes possess the most favorable properties as potential paramagnetic chemical exchange saturation transfer (PARACEST) magnetic resonance imaging (MRI) contrast agents.

Novel amide-based cationic surfactants as efficient corrosion inhibitors for carbon steel in HCl and H2SO4 media

A variety of surface active compounds were synthesized by the quaternization of some straight chain amide derivatives with triethylamine or pyridine. Their structure FT-IR and 1H-NMR spectra were recorded. In addition their physical properties and corrosion prevention efficiencies were investigated. All compounds were tested with steel coupons in acidic media by the gravimetric method. As acidic media 1.5 M HCl and 1.5 M H2SO 4 were used and the corrosion inhibition tests fulfilled at room temperature for 24 h. Almost all prepared cationic surfactants showed efficient inhibition around their critical micelle concentrations. The effects of HCl concentration on corrosion inhibition of some synthesized compounds were also investigated. The corrosion tests were supported by contact angle measurements.

Modulating the development of E. coli biofilms with 2-aminoimidazoles

The synthesis of a 20 member 2-aminoimidazole/triazole pilot library is reported. Each member of the library was screened for its ability to inhibit or promote biofilm development of either Escherichia coli and Acinetobacter baumannii. From this screen, E. coli-selective 2-aminoimidazoles were discovered, with the best inhibitor inhibiting biofilm development with an IC50 of 13 μM. The most potent promoter of E. coli biofilm formation promoted biofilm development by 321% at 400 μM.

Synthesis and evaluation of antitubercular activity of glycosyl thio- and sulfonyl acetamide derivatives

A series of glycosyl thioacetamide and glycosyl sulfonyl acetamide derivatives have been prepared following a convenient reaction protocol and evaluated for their antitubercular activity against Mycobacterium tuberculosis H37Rv. Amongst 32 compounds evaluated 3 compounds were effective in inhibiting mycobacterial growth at MIC of 6.25 μg/mL, 6 compounds at MIC of 3.125 μg/mL and 1 compound at MIC of 1.56 μg/mL. All active compounds were found nontoxic in Vero cell lines and mice bone marrow macrophages.

Evaluation of glycolamide esters of indomethacin as potential cyclooxygenase-2 (COX-2) inhibitors

A number of novel indomethacin glycolamide esters were synthesized and tested for their cyclooxygenase (COX-1 and COX-2) inhibition properties in vitro. Many of these compounds proved to be selective COX-2 inhibitors, and subtle structural changes in the substituents on the glycolamide ester moiety altered the inhibitory properties as well as potencies significantly. Their in vitro data were rationalized through molecular modeling studies. Few of them displayed anti-inflammatory activity in vivo. Compound 32, [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid 2-morpholin-4-yl-2-oxo ethyl ester, was identified as a promising compound in this class and its good anti-inflammatory activity was demonstrated in the in vivo model.