203717-22-0

Upstream product

• 203717-20-8 9-Benzyl-1-[1-(tert-butyl-dimethyl-silanyloxy)-but-3-enyl]-9H-β-carboline 
• 203717-17-3 1-(9-Benzyl-9H-β-carbolin-1-yl)-but-3-en-1-ol 
• 203717-10-6 9-benzyl-1-methoxycarbonyl-β-carboline 
• 203717-13-9 9-benzyl-9H-pyrido[3,4-b]indole-1-carbaldehyde 
• 100-44-7 benzyl chloride 
• 3464-66-2 methyl 9H-pyrido[3,4-b]indole-1-carboxylate 

Downstream Products

• 203717-27-5 (E)-5-(9-Benzyl-9H-β-carbolin-1-yl)-5-(tert-butyl-dimethyl-silanyloxy)-pent-2-enoic acid methyl ester 
• 203717-24-2 3-(9-Benzyl-9H-β-carbolin-1-yl)-3-(tert-butyl-dimethyl-silanyloxy)-propionaldehyde 

Relevant academic research and scientific papers

Synthesis of cytotoxic 1-polyhydroxyalkyl-β-carboline derivatives

dl-1-(1-Oxo-3,4-threo-3,4,5-trihydroxy-1-pentyl)-β- carboline 16a was synthesized from 1-formyl-β-carboline in 13 steps. The prepared compound is one of the diastereomers of an alkaloid 3 produced by the inter-generic somatic hybrid cell culture of Rauwolfia serpentina Benth and Rhazya stricta Decaisne (family: Apocynaceae). The N9-benzyl and N9-methyl derivatives 16b,c were also prepared. The final compounds and some of the intermediates showed cytotoxic activity against human promyelocytic leukemia cells HL 60 and/or human diploid embryonic lung fibroblast cells.