203726-34-5

Upstream product

• 2309-07-1 Methyl ferulate 
• 96-32-2 bromoacetic acid methyl ester 
• 96-34-4 methyl chloroacetate 
• 1660-19-1 (4-formyl-2-methoxyphenoxy)acetic acid 
• 1135-24-6 (E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid 
• 186581-53-3 diazomethane 
• 100519-48-0 4-carboxymethoxy-3-methoxy-trans-cinnamic acid 

Downstream Products

• 149654-18-2 dimethyl tri-O-methylmelidate A 
• 198897-22-2 methyl 2-[2-methoxy-4-(methoxycarbonylmethoxy)phenyl]cyclopropanecarboxylate 
• 731845-94-6 [3-methoxy-4-(2-methoxycarbonylethenyl)phenoxy]acetic acid 
• 198897-23-3 [3-methoxy-4-(2-methoxycarbonylcyclopropyl)phenoxy]acetic acid 

Relevant academic research and scientific papers

FUNCTIONALIZED PHENOLIC COMPOUNDS AND POLYMERS THEREFROM

The present invention relates to compounds of formula I, which are functionalized phenolic compounds, and polymers formed from the same. Ar—[O—(X)p—R′]q??I Polymers formed from the functionalized phenolics are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.

Novel Regioselective Ester Hydrolysis by Pig-Liver Esterase

Pig-liver esterase, which catalyzed the hydrolysis of substrates containing both saturated and αβ-unsaturated/cyclopropanecarboxylic esters (methyl and ethyl), was studied. An exclusive hydrolysis of the saturated esters was observed. Kinetic experiments revealed that the presence of deactivated carbonyl in the unsaturated/cyclopropanecarboxylic esters and their weaker bindings are both responsible for the observed specificity. The relative binding abilities of the substrates have been explained in light of Jones active-site model. The regioselectivity has been exploited in the synthesis of intermediates for the thromboxane synthetase inhibitor.