20377-01-9

Upstream product

• 611-34-7 5-Aminoquinoline 

Downstream Products

• 54620-48-3 5-Methoxy-quinolin-6-ylamine 
• 611-34-7 5-Aminoquinoline 
• 81852-47-3 5-cyclohexylthio-6-quinolylamine 
• 81764-39-8 Isobutyl-(9H-pyrido[3,2-c]azepin-5-yl)-amine 
• 81764-38-7 Butyl-(9H-pyrido[3,2-c]azepin-5-yl)-amine 
• 81764-40-1 tert-Butyl-(9H-pyrido[3,2-c]azepin-5-yl)-amine 
• 81764-37-6 Isopropyl-(9H-pyrido[3,2-c]azepin-5-yl)-amine 
• 6677-72-1 5,5'-azoquinoline 
• 226-49-3 dipyrido<3,2-a:3',2'-h>phenazine 
• 50358-39-9 6-bromo-5-aminoquinoline 
• 116632-58-7 8-bromo-5-aminoquinoline 
• 65417-77-8 Cyclohexyl-(9H-pyrido[3,2-c]azepin-5-yl)-amine 
• 104369-72-4 5-phenoxy-9H-pyrido<3,2-c>azepine 
• 81764-41-2 Hexyl-(9H-pyrido[3,2-c]azepin-5-yl)-amine 

Relevant academic research and scientific papers

MALT1 MODULATORS AND USES THEREOF

Provided herein are compounds, compositions, and methods useful for modulating MALT1 and for treating related diseases, disorders, and conditions.

Derivative containing aromatic ring/aromatic heterocycle-triazole-methylene-TCP and preparation method and application thereof

The invention discloses a derivative containing aromatic ring/aromatic heterocycle-triazole-methylene-TCP, which has a structure shown in a general formula I, has remarkable biological inhibition activity on LSD1, can be used for preparing a medicine for inhibiting LSD1, enriches the variety of TCP derivatives, and lays a foundation for researching and developing a novel LSD1 inhibitor. Particularly, the derivative can be used for preparing anti-tumor medicines, has a certain inhibition effect on a plurality of tumor cell strains such as gastric cancer cell strains (MGC-803, SGC-7901), breastcancer cell strains (MCF-7) and prostate cancer cell strains (PC-3), shows antitumor activity, provides a lead compound structure for anticancer drugs, and has a good application prospect. The invention also provides a preparation method of the aromatic ring/aromatic heterocycle-triazole-methylene-TCP containing derivative, (1R, 2S)-phenylcyclopropylamine or (1R, 2S)-3, 4-difluorophenylcyclopropylamine is used as a raw material, the derivative is prepared through alkyne feeding and cycloaddition reactions, the preparation method is simple, and batch production and commercial application are facilitated.

Methyl 3-cyclopropyl-3-oxopropanoate in the synthesis of heterocycles having a cyclopropyl substituent

Reactions of methyl 3-cyclopropyl-3-oxopropanoate with chloroacetone and ammonia, benzaldehyde and ammonia, and benzoquinone gave, respectively, methyl 2-cyclopropyl-5-methyl-1H-pyrrole-3-carboxylate, dimethyl 2,6-dicyclopropyl-4- phenyl-1,4-dihydropyridi

Photolysis of Quinolyl Azides in Aliphatic Thiols. Synthesis of o-Alkylthioquinolylamine

Photolysis of 5- or 8-quinolyl azide in various thiols gives o-alkylthioquinolylamines.The beneficial effect of a 6-methoxy-group in 8-quinolyl azide on the yields is noted.