203794-76-7

Upstream product

• 194603-25-3 9-((2R,3R,4R,5S,6R)-4,5-Diacetoxy-6-acetoxymethyl-3-allyloxycarbonylamino-tetrahydro-pyran-2-yloxy)-nonanoic acid methyl ester 
• 194603-23-1 9-((2R,4aR,6R,7R,8R,8aS)-7-Allyloxycarbonylamino-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-nonanoic acid methyl ester 
• 177610-00-3 9-((2R,3R,4R,5S,6R)-3-Allyloxycarbonylamino-4,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-nonanoic acid methyl ester 
• 169532-17-6 ethyl 2,3,4-tri-O-benzyl-1-thio-α/β-L-fucopyranoside 
• 76946-04-8 perbenzyl fucosyl bromide 
• 112929-24-5 1,3,4,6-tetra-O-acetyl-2-deoxy-2-(allyloxycarbonylamino)-β-D-glucopyranose 
• 1125-88-8 benzaldehyde dimethyl acetal 
• 34957-73-8 methyl 9-hydroxynonanoate 
• 203794-75-6 9-[(2R,4aR,6R,7R,8R,8aS)-7-Allyloxycarbonylamino-2-phenyl-8-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy]-nonanoic acid methyl ester 

Downstream Products

• 203794-77-8 9-[(2R,3R,4R,5S,6R)-3-Amino-6-benzyloxymethyl-5-hydroxy-4-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-nonanoic acid methyl ester 
• 203794-79-0 9-[(2R,3R,4R,5S,6R)-6-Benzyloxymethyl-3-(3,4-dimethoxy-benzoylamino)-5-hydroxy-4-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-nonanoic acid methyl ester 

Relevant academic research and scientific papers

Synthesis and biological evaluation of a sialyl Lewis X mimic with significantly improved E-selectin inhibition

The synthesis of the highly potent E-selectin inhibitor 5 is described. Sialyl Lewis X mimic 5 was rationally designed by combining two previously disclosed beneficial sLex modifications in a single molecule. The compound was found to be 30-fold more potent than sLex in a static, cell-free equilibrium assay. Furthermore, compound 5 was highly active (IC50 = 10 μM) in a dynamic non-equilibrium assay in which sLex did not inhibit neutrophil rolling at up to 1000 μM.