203806-39-7

Upstream product

• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 66384-45-0 N-acetyl-2-iodo-4,5-dimethoxy-β-phenethylamine 
• 6275-29-2 N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide 
• 203806-36-4 N-[2-(2-formyl-4,5-dimethoxy-phenyl)-ethyl]-acetamide 
• 203806-37-5 N-[2-(4,5-dimethoxy-2-vinylphenyl)ethyl]acetamide 
• 3382-18-1 6,7-dimethoxy-3,4-dihydro-isoquinoline 
• 203806-38-6 N-(tert-Butoxycarbonyl)-N-[2-(4,5-dimethoxy-2-vinylphenyl)ethyl]acetamide 
• 1384186-28-0 N-2-(2-iodo-4,5-dimethoxyphenyl)ethyl-tert-butoxycarbonylacetamide 
• 1314098-76-4 N-(tert-butoxycarbonyl)-2-(2-iodo-4,5-dimethoxyphenyl)ethylamine 
• 7486-35-3 tri-n-butyl(vinyl)tin 

Downstream Products

• 1026016-83-0 ((3R,11bR)-3-isobutyl-9.10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one) 
• 1228458-05-6 (5S,6R,E)-6-(tert-butyldimethylsilyloxy)-5-isobutyl-10,11-dimethoxy-2,3,5,6-tetrahydrobenzo[d]azecin-4(1H)-one 
• 1384186-23-5 C₅₂H₈₆N₂O₈Si₂ 
• 1228458-10-3 (2R,3S,11bR)-2-hydroxy-3-isobutyl-9,10-dimethoxy-2,3,6,7-tetrahydro-1H-pyrido[2,1-α]isoquinolin-4(11bH)-one 
• 1384186-29-1 C₄₀H₅₈N₂O₈ 
• 1384186-18-8 2-(4,5-dimethoxy-2-vinylphenyl)ethanamine 
• 1384186-21-3 (2S,3R)-3-((tert-butyldimethylsilyl)oxy)-N-(4,5-dimethoxy-2-vinylphenethyl)-2-isobutylpent-4-enamide 

Relevant academic research and scientific papers

A ring-closing metathesis-based approach to the synthesis of (+)-tetrabenazine

A modular stereoselective synthesis of the vesicular monoamine transport inhibitors (+)-tetrabenazine ((+)-1) and (+)-α-dihydrotetrabenazine ((+)-2) has been developed. The approach is based on amine 4 and acid 5 as the key building blocks, which were elaborated into macrolactam 3 by amide coupling and a subsequent highly E-selective RCM reaction. Macrolactam 3 could be converted into tetrabenazine in three known steps.

Stereoselective isoquinoline alkaloid synthesis with new diselenides

The synthesis of improved optically active selenium compounds for electrophilic additions to C=C double bonds is described. These reagents allow the formation of methoxyselenenylated products with high diastereoselectivities (up to 93% de). Intramolecular aminoselenenylations with chiral selenium electrophiles provide a short route to tetrahydroisoquinoline alkaloids.