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Usage

Uses

Used in Pharmaceutical Industry:
[4-(2-chlorophenyl)piperazin-1-yl](phenyl)methanone is used as a pharmaceutical intermediate for the synthesis of various medications. Its unique structure allows for the development of diverse pharmacologically active compounds, contributing to the creation of new treatments for a range of medical conditions.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, [4-(2-chlorophenyl)piperazin-1-yl](phenyl)methanone is utilized for the development of new drugs targeting central nervous system disorders. Its structural similarity to psychoactive substances makes it a promising candidate for designing novel therapeutic agents to address various neurological and psychiatric conditions.
Used in Psychoactive Substance Research:
Due to its potential psychoactive effects, [4-(2-chlorophenyl)piperazin-1-yl](phenyl)methanone is also used in research aimed at understanding the mechanisms of action and potential applications of psychoactive substances. This research can lead to the development of new treatments for conditions such as anxiety, depression, and other mood disorders.

Upstream product

• 39512-50-0 N-(o-Chlorophenyl)piperazine 
• 98-88-4 benzoyl chloride 
• 95-51-2 o-chloroaniline 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 13754-38-6 N-Benzoylpiperazine 

Relevant academic research and scientific papers

Synthesis of ortho -haloaminoarenes by aryne insertion of nitrogen-halide Bonds

A rapid and general access to ortho-haloaminoarenes has been developed by aryne insertion into N-chloramine, N-bromoamine, and N-iodoamine bonds via two complementary protocols harnessing fluoride-promoted 1,2-elimination of ortho-trimethylsilyl aryltriflates. Typically, electron-deficient N-chloramines effectively react with aryne intermediates generated at elevated temperature with CsF, while less stable N-haloamines are found more efficient under milder, TBAF-mediated aryne formation at room temperature. Both protocols demonstrate a good level of regioselectivity and functional group tolerance. Efforts to elucidate the mechanism of N-X insertion are also discussed. The practical value of this transformation is highlighted by rapid synthesis of novel analogues of the antipsychotic cariprazine.

Insertion of arynes into N-halo bonds: A direct approach to O -haloaminoarenes

A new approach to access o-haloaminoarenes has been achieved by insertion of arynes into a nitrogen-halide bond (N-X). This transition-metal-free transformation displays a broad substrate scope of arynes, good compatibility with functional groups, and high regioselectivity. Representative transformations of the o-haloaminoarenes are described to highlight their utility for rapid access to diversely functionalized aminoarene derivatives.