203864-63-5Relevant academic research and scientific papers
Design of novel RNA ligands that bind stem-bulge HIV-1 TAR RNA
Duca, Maria,Malnuit, Vincent,Barbault, Florent,Benhida, Rachid
supporting information; scheme or table, p. 6162 - 6164 (2010/11/04)
We report here the rational design and the synthesis of a new series of RNA ligands. These molecules are constituted of various binding motifs that interact cooperatively with HIV-1 TAR RNA, used as a model.
Synthesis of C-nucleosides designed to participate in triplex formation with native DNA: Specific recognition of an A:T base pair in DNA
Li, Jian-Sen,Gold, Barry
, p. 8764 - 8771 (2007/10/03)
We have previously described a system of 2-aminoquinoline- and 2-aminoquinazoline-based C-deoxynucleosides (TRIPsides) that are designed to be incorporated into oligomers that can specifically bind in the major groove via Hoogsteen base pairing to any seq
Introduction of peptide functions into DNA by nucleic acid peptides, NAPs
Kawakami, Junji,Wang, Zhong-Ming,Fujiki, Hiroyoshi,Izumi, Satoshi,Sugimoto, Naoki
, p. 1554 - 1555 (2007/10/03)
Nucleic acid peptides (NAPs) with a mimetic amino acid side residue at the base position of the nucleotide via an amide bond were synthesized from 3-deoxy-6-O-(4,4′-dimethoxytrityl)allonic acid methyl ester as the common precursor. Furthermore, an NAP with an octapeptide at the C1′ position was synthesized. The peptide-linked NAP exhibits both functions of the oligopeptide part and of the oligonucleotide part. Copyright
A short and efficient synthesis of 2′-deoxybenzo- and pyridoimidazole C-nucleosides
Jazouli, Mohamed,Guianvarc'h, Dominique,Soufiaoui, Mohamed,Bougrin, Khalid,Vierling, Pierre,Benhida, Rachid
, p. 5807 - 5810 (2007/10/03)
A short route to a series of 2′-deoxy-C-nucleosides featuring substituted nucleobases has been developed. The key step is the formation of the cyclized products following Mukaiyama's type amide coupling and a simple dehydration, starting from readily accessible synthons. The epimerization of the C1′-stereogenic center was avoided under mild and controlled conditions.
Synthesis of a novel pyrene-containing nucleoside and its incorporation into oligonucleotides
Frazer, Jennifer D.,Horner, Stacy M.,Woski, Stephen A.
, p. 1279 - 1282 (2007/10/03)
The synthesis of the aryl nucleoside analogue β-2'-deoxy-D-ribofuranosyl-1'-N-pyrenyl-carboxamide is described. This compound can be converted into a phosphoramidite reagent and used in solid phase oligonucleotide synthesis.
