605674-41-7Relevant academic research and scientific papers
A short and efficient synthesis of 2′-deoxybenzo- and pyridoimidazole C-nucleosides
Jazouli, Mohamed,Guianvarc'h, Dominique,Soufiaoui, Mohamed,Bougrin, Khalid,Vierling, Pierre,Benhida, Rachid
, p. 5807 - 5810 (2007/10/03)
A short route to a series of 2′-deoxy-C-nucleosides featuring substituted nucleobases has been developed. The key step is the formation of the cyclized products following Mukaiyama's type amide coupling and a simple dehydration, starting from readily accessible synthons. The epimerization of the C1′-stereogenic center was avoided under mild and controlled conditions.
