203866-63-1Relevant articles and documents
Highly efficient synthesis of 2'-O-amino nucleosides and their incorporation in hammerhead ribozymes
Karpeisky, Alexander,Gonzalez, Carolyn,Burgin, Alex B.,Beigelman, Leonid
, p. 1131 - 1134 (2007/10/03)
2'-O-Amino nucleosides were prepared from arabino nucleosides by triflate displacement with N-hydroxy phthalimide. The corresponding phosphoramidites suitable for automated oligonucleotide synthesis, were also prepared. Incorporation of 2'-O-amino uridine into position U7 of 2'-O-amino adenosine into position A9 of a hammerhead ribozyme resulted in a slight improvement of catalytic rates.