203924-61-2

Upstream product

• 141-97-9 ethyl acetoacetate 
• 203924-60-1 5Methyl-4-(2,4,6trimethyl-phenyl)-2H-pyrazol-3-ylamine 
• 105-45-3 acetoacetic acid methyl ester 

Downstream Products

• 203924-63-4 7-chloro-5-methyl-3-(2,4,6-trimethyl-phenyl)-pyrazolo[1,5-a]pyrimidine 
• 203924-64-5 7-chloro-2,5-dimethyl-3-(2,4,6-trimethylphenyl)-pyrazolo[1,5-a]pyrimidine 

Relevant academic research and scientific papers

Pyrazolo[1,5-a]pyrimidine CRF-1 receptor antagonists

A series of 3-phenylpyrazolo[1,5-a]pyrimidines was prepared and found to have affinity for the human CRF-1 receptor. The 3-dimensional structure of one of the most potent analogs in this series, 10d, was determined by X-ray crystallography and suggests the spatial requirements for potent CRF-1 receptor binding affinity in this series.

SUBSTITUTED 6,5-HETERO-BICYCLIC DERIVATIVES

This invention relates to compounds of the formula wherein A, B, D, E K, I, G, R3 and R5 are defined as in the specification, and to the pharmaceutically acceptable salts of such compounds.