Bioorganic and Medicinal Chemistry Letters p. 2067 - 2070 (1998)
Update date:2022-08-05
Topics:
Wustrow, David J.
Capiris, Thomas
Rubin, Ronald
Knobelsdorf, James A.
Akunne, Hyacinth
Duff Davis
MacKenzie, Robert
Pugsley, Thomas A.
Zoski, Kim T.
Heffner, Thomas G.
Wise, Lawrence D.
A series of 3-phenylpyrazolo[1,5-a]pyrimidines was prepared and found to have affinity for the human CRF-1 receptor. The 3-dimensional structure of one of the most potent analogs in this series, 10d, was determined by X-ray crystallography and suggests the spatial requirements for potent CRF-1 receptor binding affinity in this series.
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Doi:10.1039/a707354b
(1998)Doi:10.1016/S0957-4166(97)00617-4
(1998)Doi:10.1021/op000059q
(2000)Doi:10.1007/BF02495265
(1997)Doi:10.1007/s11176-005-0368-x
(2005)Doi:10.1002/prac.19983400203
(1998)
