Pyrazolo[1,5-a]pyrimidine CRF-1 receptor antagonists

DOI: 10.1016/S0960-894X(98)00372-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2067 - 2070 (1998)

Update date:2022-08-05

Topics:

Authors:

Wustrow, David J.

Capiris, Thomas

Rubin, Ronald

Knobelsdorf, James A.

Akunne, Hyacinth

Duff Davis

MacKenzie, Robert

Pugsley, Thomas A.

Zoski, Kim T.

Heffner, Thomas G.

Wise, Lawrence D.

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Article abstract of DOI:10.1016/S0960-894X(98)00372-2

A series of 3-phenylpyrazolo[1,5-a]pyrimidines was prepared and found to have affinity for the human CRF-1 receptor. The 3-dimensional structure of one of the most potent analogs in this series, 10d, was determined by X-ray crystallography and suggests the spatial requirements for potent CRF-1 receptor binding affinity in this series.

Full text of DOI:10.1016/S0960-894X(98)00372-2

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