203933-02-2Relevant academic research and scientific papers
Facile synthesis of benzothiadiazine 1,1-dioxides, a precursor of RSV inhibitors, by tandem amidation/ intramolecular aza-Wittig reaction
Majumdar, Krishna C.,Ganai, Sintu
supporting information, p. 503 - 509 (2013/05/08)
Reaction of o-azidobenzenesulfonamides with ethyl carbonochloridate afforded the corresponding amide derivatives, which gave 3-ethoxy-1,2,4- benzothiadiazine 1,1-dioxides through an intramolecular aza-Wittig reaction. The reaction was found to be general
An one-pot approach to the synthesis of triazolobenzothiadiazepine 1,1-dioxide derivatives by basic alumina-supported azide-alkyne [3+2] cycloaddition
Majumdar,Ganai, Sintu,Sinha, Biswajit
experimental part, p. 7806 - 7811 (2012/09/22)
An efficient one-pot strategy for the synthesis of triazolobenzothiadiazepine 1,1-dioxide derivatives has been developed by the reaction of 2-azido-N-substituted benzenesulfonamides and propargyl bromide in basic alumina under microwave condition via [3+2] azide-alkyne cycloaddition reaction. This protocol has synthetic advantages in terms of low environmental impact and short reaction time.
Synthesis of 3-amino-1,2,4-benzothiadiazine 1,1-dioxides via a tandem aza-Wittig/heterocumulene annulation
Blackburn, Christopher,Achab, Abe,Elder, Amy,Ghosh, Shomir,Guo, Jianping,Harriman, Geraldine,Jones, Matthew
, p. 10206 - 10209 (2007/10/03)
Reaction of o-azidobenzenesulfonamides with polymer-supported triphenylphosphine affords the corresponding iminophosphoranes. Subsequent reaction with isocyanates gives 3-amino-1,2,4-benzothiadiazine 1,1-dioxides in high yields and purities. The reaction
