203934-91-2

Upstream product

• 86294-60-2 (E)-1-Methoxy-1-(trimethylsiloxy)buten 
• 145451-93-0 (4R,5S)-3-Benzyl-4-(tert-butyl-dimethyl-silanyloxymethyl)-5-isopropyl-oxazolidine-4-carboxylic acid methyl ester 
• 145452-01-3 [(4R,5S)-3-Benzyl-4-(tert-butyl-dimethyl-silanyloxymethyl)-5-isopropyl-oxazolidin-4-yl]-methanol 
• 145451-90-7 (2R,4R)-3-Benzyl-2-tert-butyl-4-((S)-1-hydroxy-2-methyl-propyl)-oxazolidine-4-carboxylic acid methyl ester 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 55453-12-8 (1-methoxybut-1-enyloxy)trimethylsilane 
• 145484-22-6 (4R,5S)-3-Benzyl-4-(tert-butyl-dimethyl-silanyloxymethyl)-5-isopropyl-oxazolidine-4-carbaldehyde 

Relevant academic research and scientific papers

The structural requirements for inhibition of proteasome function by the lactacystin-derived β-lactone and synthetic analogs

The synthesis of analogs of the lactacystin-derived β-lactone (2) in which the substituents at C(5), C(7) and C(9) were systematically varied has led to a well defined structure-activity correlation for the highly selective inhibition of the mammalian 20 S proteasome.

A new magnesium-catalyzed doubly diastereoselective anti-aldol reaction leads to a highly efficient process for the total synthesis of lactacystin in quantity

A new process is described for metal-catalyzed doubly diastereoselective Mukaiyama aldol coupling of a chiral tertiary α-amino aldehyde and an achiral silyl enol ether to form selectively an anti-aldol product. The metal requirement is strict, since of se