203934-92-3Relevant articles and documents
The structural requirements for inhibition of proteasome function by the lactacystin-derived β-lactone and synthetic analogs
Corey,Li, Wei-Dong Z.,Nagamitsu, Tohru,Fenteany, Gabriel
, p. 3305 - 3316 (2007/10/03)
The synthesis of analogs of the lactacystin-derived β-lactone (2) in which the substituents at C(5), C(7) and C(9) were systematically varied has led to a well defined structure-activity correlation for the highly selective inhibition of the mammalian 20 S proteasome.