203935-00-6

Basic information

• Product Name: (1S,6R,7S,7aS)-6-Benzyl-7-hydroxy-7a-hydroxymethyl-1-isopropyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one
• Synonyms: (1S,6R,7S,7aS)-6-Benzyl-7-hydroxy-7a-hydroxymethyl-1-isopropyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one
• CAS NO: 203935-00-6
• Molecular Weight: 305.374
• Mol File: 203935-00-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (1S,6R,7S,7aS)-6-Benzyl-7-hydroxy-7a-hydroxymethyl-1-isopropyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,6R,7S,7aS)-6-Benzyl-7-hydroxy-7a-hydroxymethyl-1-isopropyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one(203935-00-6)
• EPA Substance Registry System: (1S,6R,7S,7aS)-6-Benzyl-7-hydroxy-7a-hydroxymethyl-1-isopropyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one(203935-00-6)

Safety Data

• Hazardous Substances Data: 203935-00-6(Hazardous Substances Data)

Upstream product

• 203934-94-5 (2R,3S)-2-Benzyl-3-[(4S,5S)-3-benzyl-4-(tert-butyl-dimethyl-silanyloxymethyl)-5-isopropyl-oxazolidin-4-yl]-3-hydroxy-propionic acid methyl ester 
• 145451-93-0 (4R,5S)-3-Benzyl-4-(tert-butyl-dimethyl-silanyloxymethyl)-5-isopropyl-oxazolidine-4-carboxylic acid methyl ester 
• 145484-22-6 (4R,5S)-3-Benzyl-4-(tert-butyl-dimethyl-silanyloxymethyl)-5-isopropyl-oxazolidine-4-carbaldehyde 
• 145452-01-3 [(4R,5S)-3-Benzyl-4-(tert-butyl-dimethyl-silanyloxymethyl)-5-isopropyl-oxazolidin-4-yl]-methanol 
• 145451-90-7 (2R,4R)-3-Benzyl-2-tert-butyl-4-((S)-1-hydroxy-2-methyl-propyl)-oxazolidine-4-carboxylic acid methyl ester 
• 133464-88-7 ((E)-1-Methoxy-3-phenyl-propenyloxy)-trimethyl-silane 
• 203934-94-5 (2R,3S)-2-Benzyl-3-[(3S,4S,5S)-3-benzyl-4-(tert-butyl-dimethyl-silanyloxymethyl)-5-isopropyl-oxazolidin-4-yl]-3-hydroxy-propionic acid methyl ester 

Relevant articles and documents

The structural requirements for inhibition of proteasome function by the lactacystin-derived β-lactone and synthetic analogs

The synthesis of analogs of the lactacystin-derived β-lactone (2) in which the substituents at C(5), C(7) and C(9) were systematically varied has led to a well defined structure-activity correlation for the highly selective inhibition of the mammalian 20 S proteasome.