203984-22-9Relevant academic research and scientific papers
Stereoselective synthesis of 4,5-disubstituted pyrrolidin-2-ones by cuprate addition to chiral non racemic α,β-unsaturated-γ-lactams
Baussanne, Isabelle,Royer, Jacques
, p. 845 - 848 (2007/10/03)
A new access to enantiopure 4,5-disubstituted pyrrolidin-2-ones has been developed from chiral non racemic α,β-unsaturated-γ-lactams. Conjugate addition of Gilman-type cuprates results in trans addition with excellent diastereoselectivity.
