203984-67-2

Upstream product

• 203984-66-1 2-bromo-5-(tert-butyl)-3,4-dimethoxy-1-methylbenzene 
• 34582-29-1 1-(tert-butyl)-2,3-dimethoxy-5-methylbenzene 
• 1010-99-7 3-(tert-butyl)-5-methylbenzene-1,2-diol 

Downstream Products

• 304859-80-1 Methyl 2-bromo-5-tert-butyl-3,4-dimethoxybenzoate 
• 203984-68-3 2-Bromo-5-tert-butyl-3,4-dimethoxy-benzoic acid 3-tert-butyl-2-methoxy-5-methyl-phenyl ester 

Relevant academic research and scientific papers

Atropo-anantioselective synthesis of a simplified analog of mastigophorenes A and B

A first approach to the atroposelective total synthesis of mastigophorenes is described, the directed preparation of a structurally slightly modified analog of mastigophorenes A and B, with a tert-butyl instead of a substituted, chiral cyclopentyl residue. Its (partially protected) monomeric half is dimerized by oxidative (phenolic) coupling to give the corresponding biphenyl in a racemic form, or atropo-enantioselectively via the corresponding biaryl lactone, to give the M- or, optionally, the P-enantiomeric form, by stereoselective ring opening and subsequent standard transformations.