203984-68-3

Upstream product

• 203984-67-2 2-bromo-5-tert-butyl-3,4-dimethoxybenzoic acid 
• 203984-63-8 3-benzyloxy-5-tert-butyl-4-methoxytoluene 
• 203984-62-7 2-benzyloxy-6-tert-butyl-4-methylphenol 
• 203984-66-1 2-bromo-5-(tert-butyl)-3,4-dimethoxy-1-methylbenzene 
• 34582-29-1 1-(tert-butyl)-2,3-dimethoxy-5-methylbenzene 
• 1010-99-7 3-(tert-butyl)-5-methylbenzene-1,2-diol 
• 203984-64-9 3-tert-butyl-2-methoxy-5-methylphenol 

Relevant academic research and scientific papers

Atropo-anantioselective synthesis of a simplified analog of mastigophorenes A and B

A first approach to the atroposelective total synthesis of mastigophorenes is described, the directed preparation of a structurally slightly modified analog of mastigophorenes A and B, with a tert-butyl instead of a substituted, chiral cyclopentyl residue. Its (partially protected) monomeric half is dimerized by oxidative (phenolic) coupling to give the corresponding biphenyl in a racemic form, or atropo-enantioselectively via the corresponding biaryl lactone, to give the M- or, optionally, the P-enantiomeric form, by stereoselective ring opening and subsequent standard transformations.