2040-86-0

Usage

Uses

Used in Pharmaceutical Industry:
2-Bromo-6-iodophenol is used as a synthetic intermediate for the development of pharmaceuticals, leveraging its reactivity to facilitate the synthesis of complex organic molecules with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Bromo-6-iodophenol serves as a key building block in the creation of agrochemicals, contributing to the development of effective and innovative products for agricultural use.
Used in Organic Synthesis:
2-Bromo-6-iodophenol is utilized as a versatile reactant in organic synthesis, enabling the formation of a wide range of chemical compounds for various applications, including the production of specialty chemicals and materials.
Used in Research Laboratories:
2-Bromo-6-iodophenol is also employed as a research tool in academic and industrial research settings, where its unique properties are explored for new applications and to advance the understanding of chemical reactions and mechanisms.

Upstream product

• 7305-04-6 o-bromophenyl N,N-dimethylcarbamate 
• 533-58-4 2-Iodophenol 
• 95-56-7 2-hydroxybromobenzene 
• 417698-17-0 O-2-trimethylsilylphenyl N-isopropylcarbamate 
• 899427-29-3 2-bromo-6-(trimethylsilyl)phenyl isopropylcarbamate 
• 899427-32-8 2-bromo-6-iodophenyl isopropylcarbamate 

Downstream Products

• 918304-56-0 (Z)-2-[2-benzyloxy-5-((S)-2-dibenzylamino-2-methoxycarbonyl-ethyl)-phenyl]-but-2-enoic acid 2-bromo-6-iodo-phenyl ester 

Relevant academic research and scientific papers

Halogenated method of aromatic compound

The invention belongs to the field of organic synthesis, and particularly relates to synthesis of aromatic halogens, in particular to arylamine. The invention discloses a synthesis method of a corresponding ortho-halogenated product from aromatic compounds such as carbazole and phenol. The method comprises the following steps: adding a metal sulfonate salt catalyst, aromatic amine, carbazole, phenol and other hydrogen - heteroatom-containing aromatic compound reaction substrates, a halogenation reagent and a reaction solvent at a specific reaction temperature. After the drying agent is dried, the yield of the reaction product and the nuclear magnetic characterization determining structure are determined by column chromatography. The reaction product yield is determined by gas chromatography. By adopting the method, under the cheap metal salt catalyst, a plurality of ortho-substituted brominated and chloro products can be obtained with moderate to excellent yield.

Pd(II) catalyzed ortho C-H iodination of phenylcarbamates at room temperature using cyclic hypervalent iodine reagents

A novel approach to access ortho iodinated phenols using cyclic hypervalent iodine reagents through palladium(II) catalyzed C-H activation has been developed through weak coordination. The reaction showed excellent regioselectivity, reactivity and good functional group tolerance. A unique mechanism was proposed.

Regioselective iodination of phenol and analogues using N-iodosuccinimide and p-toluenesulfonic acid

Mild and highly regioselective monoiodination of phenol and analogues is achieved in high to excellent yields at room temperature with a combination of stoichiometric p-toluenesulfonic acid and N-iodosuccinimide.

Synthesis of halogenated phenols by directed ortho-lithiation and ipso-iododesilylation reactions of O-aryl N-isopropylcarbamates

The regioselective synthesis of halogenated phenols via directed ortho-lithiation reactions of in situ N-silylated O-aryl N-isopropylcarbamates is reported. This protocol is complemented by ipso-iododesilylation reactions of C-silylated carbamates and iodine-magnesium exchange reactions, which are facilitated by the adjacent carbamoyl group. These methods provide an entry into a series of o-fluoro-, o-iodo-, and o,o′-diiodophenols in high yields which are otherwise difficult to obtain. Georg Thieme Verlag Stuttgart.