204013-06-9

Usage

Uses

Used in Pharmaceutical Research and Development:
1-(2,4-Difluorobenzyl)piperazine 2HCl is utilized as a potential drug candidate for the treatment of mental health disorders due to its ability to modulate serotonin and dopamine receptors, which are pivotal targets in such therapeutic areas.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-(2,4-Difluorobenzyl)piperazine 2HCl is used as a compound for the synthesis of new drugs, given its structural properties that can be further modified to enhance its therapeutic effects.
Used in Drug Formulation:
The 2HCl salt form of the compound is used to improve its water solubility and bioavailability, which are critical factors in drug formulation to ensure effective delivery and absorption of the medication in the body.
Used in Preclinical Studies:
1-(2,4-Difluorobenzyl)piperazine 2HCl is employed in preclinical studies to evaluate its efficacy and safety in treating various mental health conditions, providing valuable data for further development into potential therapeutic agents.

Upstream product

• 1065586-31-3 t-butyl 4-(2,4-difluorobenzyl)piperazine-1-carboxylate 
• 110-85-0 piperazine 
• 452-07-3 2,4-difluorobenzyl chloride 

Downstream Products

• 1218949-62-2 2-[4-(2,4-difluorobenzyl)piperazin-1-yl]-1-[3,4-dihydro-6,7-dimethoxyisoquinolin-2(1H)-yl]-ethanone 

Relevant academic research and scientific papers

First-Time Disclosure of CVN424, a Potent and Selective GPR6 Inverse Agonist for the Treatment of Parkinson’s Disease: Discovery, Pharmacological Validation, and Identification of a Clinical Candidate

Parkinson’s disease (PD) is a chronic and progressive movement disorder with the urgent unmet need for efficient symptomatic therapies with fewer side effects. GPR6 is an orphan G-protein coupled receptor (GPCR) with highly restricted expression in dopami

TETRAHYDROPYRIDOPYRAZINES MODULATORS OF GPR6

The present invention provides compounds of formula I: which are useful as modulators of GPR6, pharmaceutical compositions thereof, methods for treatment of conditions associated with GPR6, processes for making the compounds and intermediates thereof.

PYRIDOPYRAZINES MODULATORS OF GPR6

The present invention provides compounds of formula (I): [Formula should be entered here] which are useful as modulators of GPR6, pharmaceutical compositions thereof, methods for treatment of conditions associated with GPR6, processes for making the compo

PYRAZINES MODULATORS OF GPR6

The present invention provides compounds of formula (I): which are useful as modulators of GPR6, pharmaceutical compositions thereof, methods for treatment of conditions associated with GPR6, processes for making the compounds and intermediates thereof.

INHIBITORS OF STEAROYL-COA DESATURASE

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity.