20406-82-0 Usage
Uses
Used in Pharmaceutical Industry:
2',3'-O-Isopropylidene 5-hydroxyuridine is used as a key intermediate in the synthesis of nucleoside analogues for the development of antiviral and anticancer drugs. Its protective isopropylidene group allows for the creation of stable compounds that can be further modified to target specific biological pathways involved in viral and cancer cell replication.
Used in Research and Development:
In the field of molecular biology, 2',3'-O-Isopropylidene 5-hydroxyuridine is used as a research tool to study the structure and function of nucleic acids. Its unique properties enable the exploration of nucleic acid interactions and the mechanisms of action of various biological molecules, contributing to a deeper understanding of genetic processes and potential therapeutic interventions.
Used in Chemical Synthesis:
2',3'-O-Isopropylidene 5-hydroxyuridine is employed as a versatile building block in the synthesis of nucleoside analogues with diverse biological activities. Its protected hydroxyl groups facilitate the creation of complex molecular structures that can be tailored for specific applications, such as the development of new drugs or the investigation of novel biochemical pathways.
Check Digit Verification of cas no
The CAS Registry Mumber 20406-82-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,4,0 and 6 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 20406-82:
(7*2)+(6*0)+(5*4)+(4*0)+(3*6)+(2*8)+(1*2)=70
70 % 10 = 0
So 20406-82-0 is a valid CAS Registry Number.
20406-82-0Relevant academic research and scientific papers
Synthesis of some hydroxamic acids related to uridine: Potential inhibitors of ribonucleoside diphosphate reductase
Currid, Peter,Wightman, Richard H.
, p. 115 - 128 (2007/10/03)
5-(N-Hydroxy)carboxamidouridine (5) and 5-(N-hydroxy)carboxamido- methyluridine (6) have been synthesized; these hydroxamic acids incorporate a radical trap into a nucleoside structure, and are designed as potential inhibitors of ribonucleotide diphosphat
Transformation of Some tRNA "Wobble Uridines" to their 2-Thioanalogues
Malkiewicz, Andrzej J.,Nawrot, Barbara,Sochacka, Elzbieta
, p. 360 - 366 (2007/10/02)
2',3'-O-Isopropylidene-5-uridine (5) and 2',3'-O-isopropylidene-5-ethoxycarbonylmethoxyuridine (6) have been prepared using as the substrates 2',3'-O-isopropylidene-5-chloromethyluridine (11) and 2',3'-
Reactions of 5-bromo substituted pyrimidine nucleosides with aqueous alkalies: kinetics and mechanisms.
K?ppi,L?nnberg
, p. 768 - 775 (2007/10/02)
Kinetics for the parallel and consecutive steps of the reactions of 5-bromocytidine, 5-bromouridine and its 5'-O-methyl and 2',3'-O-isopropylidene derivatives with aqueous alkalies were studied by LC. The mechanisms of the partial reactions involved are discussed.
