204062-60-2Relevant academic research and scientific papers
Synthesis and SAR of 8-arylquinolines as potent corticotropin-releasing factor1 (CRF1) receptor antagonists
Huang, Charles Q.,Wilcoxen, Keith,McCarthy, James R.,Haddach, Mustapha,Webb, Thomas R.,Gu, Jian,Xie, Yun-Feng,Grigoriadis, Dimitri E.,Chen, Chen
, p. 3375 - 3379 (2007/10/03)
A series of 4-substituted 8-aryl-2-methylquinolines 4 was designed and synthesized as highly potent antagonists for the human CRF1 receptor. This series of compounds displayed parallel SAR to other bicyclic systems such as pyrazolo[1,5-a]pyrimidines, with several compounds possessing low nanomolar binding affinity. In addition to the high potency, the basicity of this 4-aminoquinoline core may offer CRF1 antagonists with lower lipophilicity.
Substituted6,6-hetero-bicyclicderivatives
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, (2008/06/13)
This invention relates to compounds of the formula wherein A, B, D, E, K, G, R3 and R5 are defined as in the specification, and to the pharmaceutically acceptable salts of such compounds.
