25627-20-7

Usage

Uses

Used in Pharmaceutical Industry:
[1,1'-Biphenyl]-2-amine, 2',4',6'-trimethylis used as an intermediate in the synthesis of various pharmaceutical compounds for [application reason]. Its unique structure allows for the development of new drugs with specific therapeutic properties.
Used in Research:
[1,1'-Biphenyl]-2-amine, 2',4',6'-trimethylis used as a research compound for [application reason], such as studying its chemical properties, reactivity, and potential applications in various fields.
Used in Organic Synthesis:
[1,1'-Biphenyl]-2-amine, 2',4',6'-trimethylis used as a building block in organic synthesis for [application reason], enabling the creation of complex organic molecules and materials with specific properties and functions.

Upstream product

• 694-80-4 2-bromo-1-chlorobenzene 
• 65753-85-7 2-azido-2',4',6'-trimethylbiphenyl 
• 1493-13-6 trifluorormethanesulfonic acid 
• 14872-62-9 2,4,6-trimethyl-2'-nitro-1,1'-biphenyl 
• 5980-97-2 mesitylboronic acid 
• 615-36-1 2-bromoaniline 

Downstream Products

• 62533-00-0 2'.4'.6'-Trimethyl-biphenyl-2-sulfonylchlorid 
• 204062-60-2 2-methyl-8-(2,4,6-trimethyl-phenyl)-quinolin-4-ol 
• 204062-61-3 4-chloro-2-methyl-8-(2,4,6-trimethyl-phenyl)-quinoline 

Relevant academic research and scientific papers

COLORING COMPOSITION, FABRIC PRINTING METHOD, AND DYED FABRIC

PROBLEM TO BE SOLVED: To provide a coloring composition that gives a dyed product having excellent light resistance, a fabric printing method, and a dyed fabric. SOLUTION: The present invention provides use of a specific triarylmethane compound. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPO&INPIT

Molybdenum monoaryloxide pyrrolide alkylidene complexes that contain mono-ortho-substituted phenyl imido ligands

Monaryloxide pyrrolide (MAP) molybdenum imido alkylidene complexes of the type Mo(NArX)(CHCMe2R)(Me2Pyr)(OR′) (Me2Pyr = 2,5-dimethylpyrrolide) have been prepared in which NAr X is an ortho-substituted phenylimido group (X = Cl (NAr Cl), CF3 (NArCF3), i-Pr (NAriPr), t-Bu (NArtBu), mesityl (NArM), or TRIP (TRIP = triisopropylphenyl; NArT)) and OR′ = O-2,3,5,6-(C 6H5)4C6H (OTPP), O-2,6-(2,4,6-Me3C6H2)2C 6H3 (OHMT), or O-2,6-(2,4,6-i-Pr3C 6H2)2C6H3 (OHIPT). The object was to explore to what extent relatively "large" NAr M or NArT ligands would alter the performance of MAP catalysts in reactions that have been proposed to depend upon the relative size of the imido and OR′ groups. Preliminary studies employing the ring-opening metathesis polymerization of 5,6-dicarbomethoxynorbornadiene as a measure of selectivity suggest that a single phenylimido ortho substituent, even in an NArM or NArT group, does not produce any unique behavior and that the outcome of the ROMP reaction correlates with the overall relative size of the imido and OR′ group. Single-crystal X-ray structures of six species that contain the new NArM or NArT groups are reported.

Synthesis and SAR of 8-arylquinolines as potent corticotropin-releasing factor1 (CRF1) receptor antagonists

A series of 4-substituted 8-aryl-2-methylquinolines 4 was designed and synthesized as highly potent antagonists for the human CRF1 receptor. This series of compounds displayed parallel SAR to other bicyclic systems such as pyrazolo[1,5-a]pyrimidines, with several compounds possessing low nanomolar binding affinity. In addition to the high potency, the basicity of this 4-aminoquinoline core may offer CRF1 antagonists with lower lipophilicity.

INTER- AND INTRA-MOLECULAR AROMATIC N-SUBSTITUTION BY ARYLNITRENIUM-ALUMINIUM CHLORIDE COMPLEXES GENERATED FROM ARYL AZIDES IN THE PRESENCE OF ALUMINIUM CHLORIDE

Reactions of phenyl azide with aromatic compounds ( i. e. benzene, toluene, ethylbenzene, cumene, anisole, and bromobenzene ) in the presence of AlCl3 gave diarylamines, whwreas those of phenyl azides with an electron-donating group such as Me and OMe yield little of the corresponding diarylamines ( tarformation takes place ).The reaction of 4-nitrophenyl azide with benzene in the presence of AlCl3 gave 4-nitrophenyl(phenyl)amine and a C-substitution product, 2-amino-5-nitrobiphenyl.Decomposition of 2-azidophenyl(phenyl)methane and 2-azidobiphenyls in CH2Cl2 in the presence of AlCl3 underwent an N-cyclization to afford 9,10-dihydroacridine and carbazoles, respectively, in good yields.The kinetic data on the decomposition of aryl azides and a Hammet plot ( with p= -6.0 ) for the formation of diarylamines suggest that the products are formed by an aromatic N-substitution of arylnitrenium-AlCl3 complexes via azide-AlCl3 complexes.We further argue the character of arylnitrenium-AlCl3 complexes.

N- and C-Attacks of Phenylnitrenium Ions Generated from Phenyl Azides in the Presence of Trifluoroacetic Acid and/or Trifluoromethanesulphonic Acid

Phenylnitrenium ions were generated from phenyl azides in the presence of trifluoroacetic acid (TFA) and/or trifluoromethanesulphonic acid (TFSA).Unsubstituted phenylnitrenium ions and those with an electron-withdrawing group such as NO2 or CN undergo aromatic N-substitution, whereas those with an electron-donating group such as Me, OMe, CH2Ph, or Ph undergo C-substitution, hydrogen abstraction, and tar formation.The special character of TFA and TFSA as compared with other acids is discussed.

Cyclisation of 2-Azidodiphenylmethane and 2-Azidobiphenyls by Regiospecyfic N-Attack of Arylnitrenium-Aluminium Chloride Complexes

Decomposition of 2-azidodiphenylmethane and 2-azidobiphenyls in CH2Cl2 in the presence of AlCl3 gave 9,10-dihydroacridine and carbazoles, respectively, in reasonable yields by regiospecific N-attack of an arylnitrenium-AlCl3 complex.