204079-00-5

Upstream product

• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 394-47-8 2-fluorobenzonitrile 

Downstream Products

• 1454933-34-6 C₂₂H₂₆N₂O₃ 
• 1454933-33-5 (S)-methyl 2-(2-(3,4-dihydroisoquinolin-2(1H)-yl)benzamido)-3-methylbutanoate 
• 1454933-29-9 N-cyclohexyl-2-(3,4-dihydroisoquinolin-2(1H)-yl)benzamide 
• 1454933-28-8 N-(tert-butyl)-2-(3,4-dihydroisoquinolin-2(1H)-yl)benzamide 
• 1454933-27-7 2-(3,4-dihydroisoquinolin-2(1H)-yl)-N-(2-hydroxyphenyl)benzamide 
• 1454933-26-6 N-(2-chlorophenyl)-2-(3,4-dihydroisoquinolin-2(1H)-yl)benzamide 
• 1454933-24-4 2-(3,4-dihydroisoquinolin-2(1H)-yl)-N-(o-tolyl)benzamide 
• 1454933-23-3 2-(3,4-dihydroisoquinolin-2(1H)-yl)-N-(m-tolyl)benzamide 
• 1454933-22-2 2-(3,4-dihydroisoquinolin-2(1H)-yl)-N-phenylbenzamide 
• 1454933-21-1 2-(3,4-dihydroisoquinolin-2(1H)-yl)-N-(2-methoxybenzyl)benzamide 
• 1454933-20-0 2-(3,4-dihydroisoquinolin-2(1H)-yl)-N-(4-nitrobenzyl)benzamide 
• 1454933-19-7 2-(3,4-dihydroisoquinolin-2(1H)-yl)-N-(4-methoxybenzyl)benzamide 
• 1454933-18-6 2-(3,4-dihydroisoquinolin-2(1H)-yl)-N-(4-methylbenzyl)benzamide 
• 1454933-17-5 N-benzyl-2-(3,4-dihydroisoquinolin-2(1H)-yl)benzamide 

Relevant academic research and scientific papers

Cross-Dehydrogenative Coupling of Tetrahydroisoquinolines and 2-Fluoro-1,3-benzodithiole-1,1,3,3-tetraoxide: A New Synthetic Approach to α-Monofluoromethyl Tertiary Amines

A cross dehydrogenative coupling reaction of tetrahydroisoquinolines with 2-fluoro-1,3-benzodithiole-1,1,3,3-tetraoxide had been developed. CuBr/TBHP was identified as the best catalyst and oxidant. A variety of coupling products were obtained with good t

Efficient construction of C=N double bonds via acceptorless dehydrogenative coupling

The efficient construction of C=N double bonds has been achieved by the Ir-catalyzed intramolecular acceptorless dehydrogenative cross-coupling of tertiary amines and amides. An iridium/2-hydroxypyridine complex was identified as the highly efficient catalyst. A number of quinazolinone derivatives was prepared in excellent yields. An iridium-mediated C-H activation mechanism is proposed. This finding provides an unprecedented strategy for the direct imidation of sp3 C-H bonds.

Asymmetric cross-dehydrogenative coupling enabled by the design and application of chiral triazole-containing phosphoric acids

This report describes the development of an enantioselective C-N bond-forming reaction to produce 1,2,3,4-tetrahydroisoquinoline-derived cyclic aminals catalyzed by chiral phosphate anions. Central to the success of this goal was the design of a library of 3,3′-triazolyl BINOL-derived phosphoric acids capable of forming attractive hydrogen-bonding interactions with the peptide-like substrate. We envision this work will offer an alternative to the conventional strategy of increasing catalyst steric bulk to improve enantioselectivity with BINOL-derived phosphoric acids.

Method of inhibiting neoplastic cells with imidazoquinazoline derivatives

A method for inhibiting neoplasia, particularly cancerous and precancerous lesions by exposing the affected cells to imidazoquinazoline derivatives.

Imidazoquinazoline derivatives

PCT No. PCT/JP97/03023 Sec. 371 Date Apr. 27, 1998 Sec. 102(e) Date Apr. 27, 1998 PCT Filed Aug. 29, 1997 PCT Pub. No. WO98/08848 PCT Pub. Date Mar. 5, 1998Imidazoquinoline derivatives of the formula (wherein X may be O or S) provide selective cyclic guanosine 3',5' monophosphate (cGMP)-specific phosphodiesterase (PDE) inhibitory activity. The compounds are useful for treating or ameliorating cardiovascular disease such as thrombosis, angina pectoris, hypertension, heart failure and arterial sclerosis, as well as asthma, impotence and the like.