1454933-22-2Relevant academic research and scientific papers
Copper-catalyzed N-arylation and aerobic oxidation: One-pot synthesis of tetrahydroisoquinolino[2,1-a]quinazolinone derivatives
Tian, Hua,Qiao, Hongwei,Zhu, Changjin,Fu, Hua
, p. 2694 - 2704 (2014/01/06)
An efficient and practical copper-catalyzed one-pot method for synthesis of tetrahydroisoquinolino[2,1-a]quinazolinone derivatives has been developed, and the corresponding target products were prepared in moderate to good yields. The one-pot approach underwent sequential copper-catalyzed N-arylation, intramolecular aerobic oxidative cyclization, and the newly synthesized products provided diverse structures for screening of biological molecules.
Asymmetric cross-dehydrogenative coupling enabled by the design and application of chiral triazole-containing phosphoric acids
Neel, Andrew J.,Hehn, Joerg P.,Tripet, Pascal F.,Toste, F. Dean
, p. 14044 - 14047 (2013/10/21)
This report describes the development of an enantioselective C-N bond-forming reaction to produce 1,2,3,4-tetrahydroisoquinoline-derived cyclic aminals catalyzed by chiral phosphate anions. Central to the success of this goal was the design of a library of 3,3′-triazolyl BINOL-derived phosphoric acids capable of forming attractive hydrogen-bonding interactions with the peptide-like substrate. We envision this work will offer an alternative to the conventional strategy of increasing catalyst steric bulk to improve enantioselectivity with BINOL-derived phosphoric acids.
