2041-57-8

Usage

Uses

Used in Pharmaceutical Industry:
(1-AMINOMETHYL-CYCLOHEXYL)-METHANOL is used as a chemical intermediate for the synthesis of pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique structure allows for the creation of molecules with specific biological activities, enhancing the range of treatments available in medicine.
Used in Agricultural Industry:
In agriculture, (1-AMINOMETHYL-CYCLOHEXYL)-METHANOL may be utilized as a precursor for the production of agrochemicals, such as pesticides or fertilizers, that can improve crop yield and protect plants from diseases and pests. Its role in this industry is to provide a foundation for the creation of effective and environmentally friendly agricultural products.
Used in Material Science:
(1-AMINOMETHYL-CYCLOHEXYL)-METHANOL is employed in material science as a component in the development of new materials with specific properties. Its chemical structure can be manipulated to create materials with tailored characteristics for use in various applications, such as coatings, adhesives, or polymers.
Safety Precautions:
It is crucial to handle (1-AMINOMETHYL-CYCLOHEXYL)-METHANOL with care due to its potential to cause irritation to the skin, eyes, and respiratory system upon contact or inhalation. Proper safety measures, including the use of personal protective equipment and adherence to safety protocols, should be implemented during its production, storage, and use to minimize health risks.

Upstream product

• 1130-21-8 ethyl 1-cyanocyclohexane-1-carboxylate 
• 58920-80-2 methyl 1-cyanocyclohexane-1-carboxylate 
• 111-24-0 1,5-dibromo-pentane 
• 227203-35-2 trans aminomethylcyclohexanecarboxylic acid 

Downstream Products

• 1216981-05-3 N-((1-(hydroxymethyl)cyclohexyl)methyl)-4-methylbenzenesulfonamide 
• 1159698-82-4 N-(4-chloro-1-naphthyl)-N'-(1-hydroxy-2,2-pentamethylene)propylthiourea 
• 223764-02-1 (E)-(9S,12S,18R)-12-((1R,2R,3S)-3-Chloro-2-hydroxy-1-methyl-3-phenyl-propyl)-18-(3-chloro-4-methoxy-benzyl)-9-isobutyl-8,11-dioxa-17,20-diaza-spiro[5.15]henicos-14-ene-7,10,16,19-tetraone 
• 223763-97-1 (E)-(9S,12S,18R)-18-(3-Chloro-4-methoxy-benzyl)-9-isobutyl-12-((E)-(R)-1-methyl-3-phenyl-allyl)-8,11-dioxa-17,20-diaza-spiro[5.15]henicos-14-ene-7,10,16,19-tetraone 
• 204514-17-0 1-(tert-butoxycarbonylamino-methyl)-cyclohexanecarboxylic acid 1-allyloxycarbonyl-3-methyl-butyl ester 
• 204514-28-3 1-(tert-butoxycarbonylamino-methyl)-cyclohexanecarboxylic acid 1-carboxy-3-methyl-butyl ester 
• 204514-23-8 1-(<<(tert-butoxy)carbonyl>amino>methyl)cyclohexane-1-carboxylic acid 
• 886990-05-2 [1-(benzothiazol-2-ylsulfanylmethyl)-cyclohexylmethyl]-carbamic acid tert-butyl ester 
• 886990-07-4 [1-(tert-butoxycarbonylamino-methyl)-cyclohexyl]-methanesulfinic acid 

Relevant academic research and scientific papers

Design, Synthesis, and in vitro Evaluation of P2X7 Antagonists

The P2X7 receptor is a promising target for the treatment of various diseases due to its significant role in inflammation and immune cell signaling. This work describes the design, synthesis, and in vitro evaluation of a series of novel derivatives bearing diverse scaffolds as potent P2X7 antagonists. Our approach was based on structural modifications of reported (adamantan-1-yl)methylbenzamides able to inhibit the receptor activation. The adamantane moieties and the amide bond were replaced, and the replacements were evaluated by a ligand-based pharmacophore model. The antagonistic potency of the synthesized analogues was assessed by two-electrode voltage clamp experiments, using Xenopus laevis oocytes that express the human P2X7 receptor. SAR studies suggested that the replacement of the adamantane ring by an aryl-cyclohexyl moiety afforded the most potent antagonists against the activation of the P2X7 cation channel, with analogue 2-chloro-N-[1-(3-(nitrooxymethyl)phenyl)cyclohexyl)methyl]benzamide (56) exhibiting the best potency with an IC50 value of 0.39 μΜ.

2-substituted homotaurine derivative

The invention provides preparation and applications of a 2-substituted homotaurine derivative or a stereoisomer or a salt thereof, wherein the 2-substituted homotaurine derivative is represented by aformula I. According to the invention, the pharmacodynamic test results show that the 2-substituted homotaurine derivative is excellent in alcohol inhibition effect and has ideal application prospectof alcohol inhibition drugs.

HETEROCYCLIC COMPOUNDS AND USE THEREOF AS MODULATORS OF TYPE III RECEPTOR TYROSINE KINASES

Provided herein are heterocyclic compounds for treatment of CSF1R, FLT3, KIT, and/or PDGFRβ kinase mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and compositions.

Synthesis of oxazolidin-2-ones and imidazolidin-2-ones directly from 1,3-diols or 3-amino alcohols using iodobenzene dichloride and sodium azide

A general and efficient method for the synthesis of oxazolidin-2-ones and imidazolidin-2-ones directly from 1,3-diols and 3-amino alcohols has been developed using the same reagent combination of iodobenzene dichloride (PhICl2) and sodium azide (NaN3).

Synthesis and biological evaluation of cryptophycin analogs with substitution at C-6 (fragment C region)

Analogs of the antitumor agents cryptophycins 1 and 8 with dialkyl substitution at C-6 (fragment C) were synthesized and evaluated for in vitro cytotoxicity against human leukemia cells (CCRF-CEM). The activity of these analogs decreased as the size of the substituents at C-6 increased. The C-6 spirocylopropyl compound (2g) was highly potent in vitro and showed excellent antitumor activity in animal models.