204129-91-9Relevant academic research and scientific papers
Heterocyclic metalloprotease inhibitors
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, (2008/06/13)
The invention provides compounds of formula as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibitors of metallop
Design, synthesis, and biological evaluation of potent thiazine- and thiazepine-based matrix metalloproteinase inhibitors
Almstead, Neil G.,Bradley, Rimma S.,Pikul, Stanislaw,De, Biswanath,Natchus, Michael G.,Taiwo, Yetunde O.,Gu, Fei,Williams, Lisa E.,Hynd, Barbara A.,Janusz, Michael J.,Dunaway, C. Michelle,Mieling, Glen E.
, p. 4547 - 4562 (2007/10/03)
The synthesis and enzyme inhibition data for a series of thiazine- and thiazepine-based matrix metalloproteinase (MMP) inhibitors are described. The thiazine- and thiazepine-based inhibitors were discovered by optimization of hetererocyclic sulfonamide-ba
