204130-58-5Relevant academic research and scientific papers
Interaction of barbituric acids with o-dialkylaminobenzaldehydes
Krasnov, Konstantin A.,Kartsev, Viktor G.,Khrustalev, Victor N.
, p. 52 - 54 (2006)
Barbituric or 2-thiobarbituric acids interact with o- dialkylaminobenzaldehydes to give 5-o-dialkylaminobenzylidene derivatives, which cyclise into 2,4,6-trioxoperhydropyrimidine-5-spiro-3′-(1′, 2′,3′,4′-tetrahydroquinolines) under mild conditions; the me
Inhibitors of HPV E1 helicase enzyme
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, (2008/06/13)
The invention is concerned with novel benzodiazepine derivatives, a process for their manufacture, pharmaceutical compositions and the use of such compounds in medicine. In particular, the compounds are inhibitors of the human papillomavirus E1 helicase enzyme which is involved in viral replication. Consequently the compounds of this invention may be advantageously used as therapeutic agents for HPV mediateddiseases.
Nitroarylhydroxymethylphosphonic acids as inhibitors of CD45
Beers, Scott A.,Malloy, Elizabeth A.,Wu, Wei,Wachter, Michael P.,Gunnia, Uma,Cavender, Druie,Harris, Crafford,Davis, Janet,Brosius, Ruth,Pellegrino-Gensey, J. Lee,Siekierka, John
, p. 2203 - 2211 (2007/10/03)
A series of nitroarylhydroxymethylphosphonic acids was synthesized and evaluated as inhibitors of CD45. It was discovered that both the alpha hydroxy and nitro groups are essential for activity. Potency is enhanced by the addition of a large lipophilic group on the aryl ring adjacent to the phosphonic acid moiety. Kinetics studies have shown that these compounds are competitive inhibitors and thus bind at the active site of this enzyme.
