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20417-61-2

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20417-61-2 Usage

Description

ETHYL 2-FORMYL-1-CYCLOPROPANECARBOXYLATE is a chemical compound formed by an acid-catalyzed reaction between acrolein and ethyl diazoacetate. It serves as a reagent in the design, synthesis, and biological evaluation of first-in-class dual-acting histone deacetylase (HDACs) and phosphodiesterase 5 (PDE5) inhibitors for the treatment of Alzheimer's disease.

Uses

Used in Pharmaceutical Industry:
ETHYL 2-FORMYL-1-CYCLOPROPANECARBOXYLATE is used as a reagent for the design and synthesis of dual-acting HDAC and PDE5 inhibitors, which are being evaluated for their potential in treating Alzheimer's disease.
Used in Chemical Synthesis:
ETHYL 2-FORMYL-1-CYCLOPROPANECARBOXYLATE is used in the preparation of ethyl trans-2-(4-(methylphenyl)sulfonyl-4,5-dihydrooxazol-5-yl)cyclopropanecarboxylate, a compound that may have potential applications in various chemical processes or industries.

Check Digit Verification of cas no

The CAS Registry Mumber 20417-61-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,4,1 and 7 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 20417-61:
(7*2)+(6*0)+(5*4)+(4*1)+(3*7)+(2*6)+(1*1)=72
72 % 10 = 2
So 20417-61-2 is a valid CAS Registry Number.
InChI:InChI=1/C7H10O3/c1-2-10-7(9)6-3-5(6)4-8/h4-6H,2-3H2,1H3

20417-61-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl 2-formylcyclopropane-1-carboxylate

1.2 Other means of identification

Product number -
Other names Ethyl 2-formylcyclopropanecarboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:20417-61-2 SDS

20417-61-2Downstream Products

20417-61-2Relevant articles and documents

Anhydrous Hydrogen Iodide-Mediated Reductive Indolization of in Situ-Generated Cyclopropyl Hydrazones

Fujioka, Hiroki,Takeda, Norihiko,Ueda, Masafumi,Yasui, Motohiro

supporting information, (2021/12/17)

Fischer-type indolization of N-aryl-C-cyclopropyl hydrazones generated in situ followed by chemoselective reduction using tert-butyl iodide as an anhydrous HI generator was developed. This protocol provides indoles bearing carboxylic acid derivative units. A series of control experiments indicated the HI-mediated formation and reduction of spirocyclopropyl indolenines. Anhydrous HI functions as a Br?nsted acid as well as a reducing agent, facilitating the successful conversion of unstable reaction intermediates and iodinated mixtures in equilibrium.

Photo/N-Heterocyclic Carbene Co-catalyzed Ring Opening and γ-Alkylation of Cyclopropane Enal

Dai, Lei,Ye, Song

supporting information, p. 986 - 990 (2020/02/28)

An unprecedented photo/NHC-co-catalyzed ring-opening C-C bond cleavage of cyclopropane enal and the following γ-alkylation with a halogenated compound via radicals were established, affording the corresponding γ-alkylated α,β-unsaturated esters in moderate to good yields.

Acid catalyzed reactions of α,β-unsaturated aldehydes and ethyl diazoacetate

Branstetter, Bryan,Hossain, M. Mahmun

, p. 221 - 223 (2007/10/03)

The formation of cyclopropanes from α,β-unsaturated aldehydes and diazo compounds has been a rather challenging goal due to the extremely reactive aldehyde starter. Herein, our group reports the first formation of ethyl 2-formyl-1-cyclopropanecarboxylate in 100% yield from the acid catalyzed reaction between acrolein and ethyl diazoacetate (EDA).

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