204204-26-2Relevant academic research and scientific papers
Synthesis and biological activity of oxo-7H-benzo[e]perimidine-4- carboxylic acid derivatives as potent, nonpeptide corticotropin releasing factor (CRF) receptor antagonists
Luthin, David R.,Rabinovich, Aleksandr K.,Bhumralkar, Dilip R.,Youngblood, Kenna L.,Bychowski, Richard A.,Dhanoa, Daljit S.,John M, May
, p. 765 - 770 (1999)
A novel series of derivatives of oxo-7H-benzo[e]perimidine-4-carboxylic acid (I) potently displaced radioligand binding of 125I-CRF to both CRF1 and CRF2 receptors. The members of this series antagonized CRF-stimulated cAMP formation and CRF-stimulated corticotropin release from rat pituitary in vivo. These are the first nonpeptide antagonists to show activity at both CRF1 and CRF2 receptors.
