Bioorganic and Medicinal Chemistry Letters p. 765 - 770 (1999)
Update date:2022-08-03
Topics:
Luthin, David R.
Rabinovich, Aleksandr K.
Bhumralkar, Dilip R.
Youngblood, Kenna L.
Bychowski, Richard A.
Dhanoa, Daljit S.
John M, May
A novel series of derivatives of oxo-7H-benzo[e]perimidine-4-carboxylic acid (I) potently displaced radioligand binding of 125I-CRF to both CRF1 and CRF2 receptors. The members of this series antagonized CRF-stimulated cAMP formation and CRF-stimulated corticotropin release from rat pituitary in vivo. These are the first nonpeptide antagonists to show activity at both CRF1 and CRF2 receptors.
View MoreNantong Baokai Chemical Co., Ltd (Hangzhou Baokai Bio-Chemicals Co.,Ltd.)
Contact:+86-513-83886111
Address:No. 68 Suzhou road ,Binjiang Fine Chemical Industrial Park , Beixin town, Qidong city ,Jiangsu province
Contact:+ 86 512 52491118
Address:1 Fuyu Road, Haiyu TownChangshu, Jiangsu, China
Xinchang Yueding Chemical Co., Ltd.
Contact:86-571-56926323
Address:NO.90 BEIMENCHENGWAI CHENGGUAN TOWN XINCHANG
Contact:+65 9658 0999
Address:26 Sin Ming Lane, Midview City, #05-118, Singapore 573971
Tianjin Tongde Biological Technology Co., Ltd.
Contact:86-22-23309138
Address:Room 402, bulidingE3 Detection certification park, XiQingDistrict, Tianjin City
Doi:10.1016/S0968-0896(02)00131-1
(2002)Doi:10.1021/ol301566f
(2012)Doi:10.1016/j.tet.2011.05.034
(2011)Doi:10.1021/ja01632a019
(1954)Doi:10.1039/b203891a
(2002)Doi:10.1021/ja027670k
(2003)
