Bioorganic and Medicinal Chemistry Letters p. 765 - 770 (1999)
Update date:2022-08-03
Topics:
Luthin, David R.
Rabinovich, Aleksandr K.
Bhumralkar, Dilip R.
Youngblood, Kenna L.
Bychowski, Richard A.
Dhanoa, Daljit S.
John M, May
A novel series of derivatives of oxo-7H-benzo[e]perimidine-4-carboxylic acid (I) potently displaced radioligand binding of 125I-CRF to both CRF1 and CRF2 receptors. The members of this series antagonized CRF-stimulated cAMP formation and CRF-stimulated corticotropin release from rat pituitary in vivo. These are the first nonpeptide antagonists to show activity at both CRF1 and CRF2 receptors.
View MoreTianjin SPHINX SCIENTIFIC LAB.
Contact:+86-022-66211289
Address:Tianda high-tech Park. No.80,the 4th Avenue
Contact:+86-571-86025531 / 86024803
Address:1218-24 Guangyin Mansion,42 Fengqi East Road
HANGZHOU FOREWIN PHARMA CO., LTD
Contact:+86-571-89053961
Address:hangzhou
Shanghai Sinofluoro Scientific Co., Ltd
Contact:+86-21-64279360
Address:Room 1006,Building 3,#58 East Xinjian Road, Shanghai ,201100,China,
Taizhou Elitechemie MediPharma Technology Co.,Ltd.
Contact:+86-523-86810021
Address:Building G14,NO.1 Avenue,China Medical City, Taizhou, Jiangsu,China
Doi:10.1016/S0968-0896(02)00131-1
(2002)Doi:10.1021/ol301566f
(2012)Doi:10.1016/j.tet.2011.05.034
(2011)Doi:10.1021/ja01632a019
(1954)Doi:10.1039/b203891a
(2002)Doi:10.1021/ja027670k
(2003)
