20423-54-5Relevant academic research and scientific papers
Photoredox asymmetric catalytic enantioconvergent substitution of 3-chlorooxindoles
Jiang, Zhiyong,Li, Yunqiang,Qiao, Baokun,Zeng, Guangkuo,Zhao, Xiaowei
supporting information, p. 11362 - 11365 (2019/09/30)
An enantioconvergent substitution of 3-substituted 3-chlorooxindoles with N-aryl glycines under visible light irradiation is reported. A transition-metal-free cooperative catalysis platform with a dicyanopyrazine-derived chromophore (DPZ) as a photoredox catalyst and a chiral Br?nsted acid catalyst is effective for these transformations, which involve a single-electron transfer redox step and an enantioselective radical coupling. A variety of valuable chiral 3-aminomethylene-3-substituted oxindoles can be directly synthesized with high yields and enantioselectivities.
