88097-40-9

Upstream product

• 88097-37-4 Acetic acid 2-(4-chloro-phenyl)-1-methyl-1H-indol-3-yl ester 
• 106-39-8 bromochlorobenzene 
• 2058-74-4 1-methyl-1H-indole-2,3-dione 
• 91-56-5 indole-2,3-dione 
• 172983-88-9 1-(4-chlorophenyl)-2-(methyl(phenyl)amino)ethanone 
• 1679-18-1 4-Chlorophenylboronic acid 
• 104132-79-8 2-(4-chlorophenyl)-2-oxoacetyl chloride 
• 7099-88-9 4-chlorophenylglyoxylic acid 
• 1309455-55-7 N-(2-chlorophenyl)-2-(4-chlorophenyl)-N-methyl-2-oxoacetamide 
• 1268136-05-5 C₁₄H₉Cl₂NO₂ 
• 873-77-8 (4-chlorphenyl)magnesium bromide 

Downstream Products

• 3335-94-2 3-(4-chlorophenyl)-1-methylindolin-2-one 
• 1309455-85-3 3-(biphenyl-4-yl)-3-hydroxy-1-methylindolin-2-one 
• 20423-54-5 (+/-)-3-Chlor-3-<4-chlor-phenyl>-1-methyl-indolin-2-on 
• 1356053-22-9 C₂₄H₁₉ClN₂O 

Relevant academic research and scientific papers

Copper-Catalyzed Asymmetric Propargylic Alkylation with Oxindoles: Diastereo- A nd Enantioselective Construction of Vicinal Tertiary and All-Carbon Quaternary Stereocenters

A copper-catalyzed asymmetric propargylic alkylation of propargylic acetates with 3-substituted oxindoles for the stereoselective construction of vicinal tertiary and all-carbon quaternary stereocenters in a 3,3-disubstituted oxindole skeleton has been realized. The reaction proceeded smoothly under the catalysis of Cu(MeCN)4PF6combined with a chiral tridentate ferrocenyl P,N,N ligand, leading to a broad range of optically active 3,3-disubstituted oxindoles in high yields and with excellent diastereo- A nd enantioselectivities.

Photoredox asymmetric catalytic enantioconvergent substitution of 3-chlorooxindoles

An enantioconvergent substitution of 3-substituted 3-chlorooxindoles with N-aryl glycines under visible light irradiation is reported. A transition-metal-free cooperative catalysis platform with a dicyanopyrazine-derived chromophore (DPZ) as a photoredox catalyst and a chiral Br?nsted acid catalyst is effective for these transformations, which involve a single-electron transfer redox step and an enantioselective radical coupling. A variety of valuable chiral 3-aminomethylene-3-substituted oxindoles can be directly synthesized with high yields and enantioselectivities.

Palladium-catalyzed selective synthesis of 3-hydroxy-2-oxindoles via cascade C-H cycloaddition and oxidation of α-Aminoacetophenones

A novel method for the synthesis of 3-hydroxy-2-oxindole (3-hydroxyindolin-2-one) derivatives by palladium-catalyzed tandem C-H cycloaddition and oxidation of α-Aminoacetophenone has been developed. In the presence of Pd(OAc)2 and AgOAc, a variety of 3-hy

Palladium-catalyzed asymmetric allylic alkylation of 3-aryloxindoles with allylidene dipivalate: A useful enol pivalate product

Triple A: The catalytic asymmetric allylic alkylation (AAA) of 3-aryloxindoles with allylidene dipivalate is described. This reaction affords stable, synthetically useful enol pivalates in high yield and with excellent regio- and enantioselectivity. A broad range of substrates is tolerated, including unprotected and 3-heteroaryl nucleophiles. Copyright

Nickel-catalyzed intramolecular nucleophilic addition of aryl or vinyl chlorides to α-ketoamides through C-Cl bond activation

Nickeleophilic addition! The first example of a nickel-catalyzed direct intramolecular nucleophilic addition of aryl or vinyl chlorides to α-ketoamides through C-Cl bond activation is reported, which takes place under mild reaction conditions (see scheme).

Copper-catalyzed arylation of indolin-2,3-ones with arylboronic acids

A convenient and efficient Cu(OTf)2-catalyzed arylation of indolin-2,3-ones with arylboronic acids using cheap 1,10-phenanthroline hydrate as ligand was developed under air atmosphere, achieving 3-aryl-3-hydroxy-2- oxindoles in good to excellen

Mo-catalyzed regio-, diastereo-, and enantioselective allylic alkylation of 3-aryloxindoles

A highly regio-, diastereo-, and enantioselective allylic alkylation reaction mediated by a chiral molybdenum catalyst has been developed as a novel entry into synthetically versatile 3-alkyl-3-aryloxindoles. Extremely bulky nucleophiles were employed to

Oxidation of Indoles with Lead Tetra-acetate and Hydrolysis of 1,2-Disubstituted Indol-3-yl Acetates

Oxidation of some 1,2-disubstituted indoles with lead tetra-acetate gives the corresponding 3-acetoxy derivatives.Similar oxidation of ethyl indole-2-carboxylate affords an acetoxylated 3,3'-bi-indolyl product; methyl 1-methylindol-3-yl acetate is acetoxylated at the benzylic position of the side-chain.Alkaline hydrolysis of 1,2-disubstituted indol-3-yl acetates is accompanied by autoxidation and rearrangement to give dioxindoles, but hydrolysis of 2-ethoxycarbonyl-1-methylindol-3-yl acetate gives N,N'-dimethyl derivatives of indigo and indirubin.