20424-00-4 Usage
Description
Deprodone propionate is a new topical antiinflammatory corticosteroid. In animal
studies, it exhibited an extremely low skin irritation rate. Another potential use is as an
antiasthmatic agent.
Originator
Boots (United Kingdom)
Uses
Ester of 21-Deoxyprednisolone 17α-Propionate is a topical antiinflammatory agent.
Brand name
Eclar
Check Digit Verification of cas no
The CAS Registry Mumber 20424-00-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,4,2 and 4 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 20424-00:
(7*2)+(6*0)+(5*4)+(4*2)+(3*4)+(2*0)+(1*0)=54
54 % 10 = 4
So 20424-00-4 is a valid CAS Registry Number.
InChI:InChI=1/C24H32O5/c1-5-20(28)29-24(14(2)25)11-9-18-17-7-6-15-12-16(26)8-10-22(15,3)21(17)19(27)13-23(18,24)4/h8,10,12,17-19,21,27H,5-7,9,11,13H2,1-4H3/t17-,18-,19-,21+,22-,23-,24-/m0/s1
20424-00-4Relevant articles and documents
Process for the preparation of 21-desoxy-17-acyloxy-4-pregnenes and of 21-iodo-21-desoxy-17-acyl oxy-4-pregnene intermediates useful therein
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, (2008/06/13)
21-Desoxy-17α-acyloxy-20-keto-4-pregnenes having physiological properties are prepared by the reaction of a 17α,21-dihydroxy-20-keto-4-pregnene 17α,21-orthoester or a 21-iodo-21-desoxy-17α-acyloxy-20-keto-4-pregnene with an iodide reagent selected from the group consisting of triphenylsilyl iodide, tri-lower alkylsilyl iodide and triphenylmethyl iodide. When said 17α,21-dihydroxy-20-keto-4-pregnene 17α,21-orthoester is reacted with less than two molar equivalents of a tri-lower alkylsilyl iodide reagent there is also formed a 21-iodo-21-desoxy-17-α -acyloxy-20-keto-4-pregnene, a useful intermediate, which, upon reaction with additional iodide reagent, is converted to the corresponding 21-desoxy-17α-acyloxy-20-keto-4-pregnene.
