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Tris[2-(N-salicylideneamino)ethyl]amine, also known as TSAE, is a complex organic compound with the chemical formula C27H30N6O3. It is a tridentate ligand, meaning it can form three coordinate bonds with a central metal ion. TSAE is derived from the condensation of tris(2-aminoethyl)amine with salicylaldehyde, resulting in a Schiff base ligand. This ligand is known for its ability to form stable complexes with various metal ions, which can be used in a wide range of applications, including catalysis, sensing, and medicinal chemistry. The structure of TSAE provides a rigid framework that can enhance the stability and selectivity of the resulting metal complexes, making it a valuable component in the design of new materials and compounds.

20425-75-6

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20425-75-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 20425-75-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,4,2 and 5 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 20425-75:
(7*2)+(6*0)+(5*4)+(4*2)+(3*5)+(2*7)+(1*5)=76
76 % 10 = 6
So 20425-75-6 is a valid CAS Registry Number.

20425-75-6Relevant academic research and scientific papers

A cap-type Schiff base acting as a fluorescence sensor for zinc(ii) and a colorimetric sensor for iron(ii), copper(ii), and zinc(ii) in aqueous media

Kim, Kyung Beom,Kim, Hyun,Song, Eun Joo,Kim, Sumi,Noh, Insup,Kim, Cheal

, p. 16569 - 16577 (2013)

A simple and low cost chemosensor is described. This sensor could simultaneously detect three biologically important metal ions through fluorogenic (Zn2+) and chromogenic (Fe2+, Cu2+, and Zn2+) methods in aqueou

Synthesis, characterization, and antibacterial activities of Cr(III), Co(III), Ni(II), and Mn(III) complexes of heptadentate Schiff base ligand derived from tris(2-aminoethyl)amine

Matin,Khojasteh

, p. 1763 - 1767 (2015)

This is the first study of the antibacterial activity of heptadentate Schiff base ligand (trensal) and its Cr(III), Co(III), Ni(II), and Mn(III) complexes that have been synthesized from the heptadentate Schiff base ligand derived from salicylaldehyde and

Synthesis and characterization of 5- and 7-donor Schiff base ligands and spectroscopic evidence for tautomerism: A crystal structure showing tautomeric forms within one ligand

Ogutu, Hezron F.O.,Saban, Waheed,Malgas-Enus, Rehana,Luckay, Robert C.

, p. 392 - 402 (2019/03/11)

An improved method for the synthesis of fifteen Schiff base ligands, of which six are novel, are reported. Optimised yields were obtained and the ligands have been fully characterized via several analytical techniques. It was found that tautomeric forms o

Synthesis, characterization and crystal structure of CD(II) complex with potentially heptadentate Schiff base ligand

Ranjineh Khojasteh, Roya,Jalali Matin, Sara

, p. 83 - 87 (2016/07/15)

(Formula presented) The heptadentate N4O3-type Schiff base was derived from the condensation reaction of salicylaldehyde and tris(2-aminoethyl)amine. The heptadentate Schiff base ligand was characterized by elemental analysis, 1

Synthesis, spectral characterization, and luminescence properties of a cup-like ligand and its magnesium(II) complex

Tai, Xi-Shi,Zhao, Wen-Hua

, p. 2075 - 2082 (2014/05/06)

A new tripodal ligand, N,N,N-tri(salicylaldehyde)triaminotriethylamine (1) has been synthesized and characterized by elemental analysis, IR and UV spectroscopy, MS, and X-ray crystallography. X-ray diffraction analysis reveals that the three chains of the

Encapsulating ruthenium and osmium with tris(2-aminoethyl)amine based tripodal ligands

Mandal, Soumik,Seth, Dipravath K.,Gupta, Parna

experimental part, p. 167 - 175 (2012/03/13)

The reaction of a series of tripodal ligands, H3L1,2 and L3-6, with [M(PPh3)2Cl2] (M = Ru, Os) affords a family of coordination cage compounds of the type [M IIIL1,2]

Benign routes for the syntheses of polydentate Schiff base and their lanthanide complexes

Habib, Mohammad,Sain, Sushama,Das, Babulal,Chandra, Swapan K.

experimental part, p. 1501 - 1508 (2012/04/23)

Tris-imine septadentate Schiff base ligand has conveniently made in high yield (~95% or more), when tris(2-aminoethyl)araine condensed with salicylaldehyde using 1:3 molar ratio under solvent free conditions. Lanthanide complexes have also synthesised by

Prochelators triggered by hydrogen peroxide provide hexadentate iron coordination to impede oxidative stress

Leed, Marina G.D.,Wolkow, Natalie,Pham, David M.,Daniel, Catherine L.,Dunaief, Joshua L.,Franz, Katherine J.

experimental part, p. 1161 - 1172 (2012/05/04)

Prochelators are agents that have little affinity for metal ions until they undergo a chemical conversion. Three new aryl boronate prochelators are presented that are responsive to hydrogen peroxide to provide hexadentate ligands for chelating metal ions.

Metal complexes of tripodal ligands

-

Page/Page column 11-12, (2008/06/13)

Novel metal complexes of tripoadal ligands are useful as catalysts to enhance the action of peroxygen compounds in washing, cleaning and disinfecting processes.

Inhibition of Trypanosoma cruzi epimastigotes in vitro by iron chelating agents

Jones, Mark M.,Singh, Pramod K.,Lane, Joshua E.,Rodrigues, Rodrigo R.,Nesset, Anna,Suarez, Cristina C.,Bogitsh, Burton J.,Carter, Clint E.

, p. 1158 - 1162 (2007/10/03)

The relative effectiveness of 20 iron chelating agents in suppressing the growth and multiplication of Trypanosoma cruzi epimastigotes has been examined in vitro. 1,2-Dimethyl-3-hydroxypyrid-4-one (L1) and several of its newly synthesized N-substituted analogs containing hydrophobic substituents were significantly more effective than deferoxamine, even though they possess only two donor sites for iron(III) while deferoxamine has six. Analogs with hydrophilic substituents were uniformly less active than L1 itself. Variations in effectiveness as the polarity of the compounds is varied indicate that the ability to cross the cellular membrane is of critical importance in the determination of the in vitro trypanocidal activity of iron(III) chelating agents. A group of four tris(2-aminoethyl)amine based tris-imines were also screened, all of which had poor activity (0-28% inhibition). Among the other iron(III) chelating agents which showed a relatively high level of activity at 50 and 100 μg/ml were salicylhydroxamic acid (70 and 73% inhibition) and hydroxyurea (42 and 52% inhibition). N,N'-Di(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid and acetohydroxamic acid exhibited only slight activity at 50 and 100 μg/ml. The best of these iron(III) chelating agents were as effective against the epimastigote form at both 50 and 100 μg/ml (74-82% inhibition) as benznidazole (81% inhibition), the drug currently used in the clinic.

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