2043-20-1

Upstream product

• 107569-60-8 N-Phenyl-benzimidic acid 4-acetyl-2-nitro-phenyl ester 
• 18640-58-9 3-nitro-4-bromoacetophenone 
• 62-53-3 aniline 
• 127-09-3 sodium acetate 

Downstream Products

• 220496-06-0 1-[3-amino-4-(phenylamino)phenyl]ethan-1-one 
• 13535-48-3 1-(1-phenyl-1H-benzotriazol-5-yl)-ethanone 

Relevant academic research and scientific papers

Double (amino-sulfur generation of formic acid ) - 1,3-propane diester compound and its synthetic method, pharmaceutical composition and use thereof

The invention relates to a bis(aminodithioformate)-1,3-propane diester compound, and synthesis method thereof, a pharmaceutical composition containing the compound and a use, and especially relates to the use in preparing drugs for treating or preventing cancers. The compound is represented as the formula (I), wherein A is selected from substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclic group, R1 and R2 are the same or different and are independently selected from hydrogen, alkyl, aryl alkyl or heteroaryl alkyl, or a substituted or unsubstituted heterocyclic ring formed together by the R1, the R2 and an N atom connected with the R1 and the R2.

Discovery and optimization of novel dual dithiocarbamates as potent anticancer agents

A series of dual dithiocarbamates were synthesized and evaluated for their in-vitro anticancer activities on human non-small cell lung cancer cell line H460. Nine compounds exhibited significant antiproliferative activities with IC50 less than 1 μM. Among them, compound 14m showed the highest inhibitory activity against H460 cell and inhibited the growth of nine types of tumor cells with IC50 values less than 1 μM. It also achieved IC50 of 54 nM and 23 nM against HepG2 and MCF-7 cell lines, respectively. Preliminary structure-activity relationship study indicated that: a) when the methyl group (region A) is substituted with benzene rings, ortho substitution on the benzene ring is favored for activity; b) substitution with heterocyclic structures at region A exhibited greater impact on the anti-tumor activity of compounds, in which pyridine ring, thiazole ring, coumarin and benzo[b]thiophene are favored and quinoline ring is the most favored; c) substitution with different amines (region B) also showed marked effect on the activity of compounds and dimethylamine and morpholine are preferred to other tested amines.

REACTIONS OF IMIDIC ACID DERIVATIVES WITH NUCLEOPHILIC REAGENTS. MECHANISM OF THE ALKALINE HYDROLISIS OF ARYL N-ARYLARENECARBOXIMIDATES

In the kinetics of the alkaline hydrolysis of aryl-N-phenylbenzimidates PhC(OArX) =NPh(I) in a water-dioxane mixture (1:1 by volume) and with a constant ionic strength in 0.2 M sodium perchlorate first order is observed in each of the reagents.The Hammett ρ and Bronsted β parameters with variation of the substituent in the leaving group are 1.6 and -0.35 respectively.The products from the hydrolysis of compounds (I) (X = 2,4-(NO2)2, 2-NO2-4-COCH3) are benzoic acid and substituted diphenylamines and, in the case of the derivatives of (I) benzanilide and the corresponding phenol.In spite of the different qualitative composition of the hydrolysis products the data for all the substituents (including the ortho substituents) satisfy the Hammett and Bronsted equations.The results are explained in terms of an addition-elimination stage mechanism with the formation of a tetrahedral intermediate product in the rate-determining stage.