20432-97-7

Usage

Uses

Used in Pharmaceutical Research and Development:
2-amino-N-benzylacetamide hydrochloride is used as a building block for potential drug candidates due to its structural features that allow for versatile chemical modifications and potential biological activity. Its synthesis through a multistep organic synthesis process and its enhanced solubility in water due to the hydrochloride salt form make it a valuable component in the discovery and development of new pharmaceuticals.
Used in Drug Discovery:
In the drug discovery industry, 2-amino-N-benzylacetamide hydrochloride is used as a starting material for the synthesis of various compounds with potential therapeutic effects. Its unique structure allows for the exploration of different chemical modifications that could lead to the development of novel drugs with improved efficacy and safety profiles.
Used in Chemical Synthesis:
2-amino-N-benzylacetamide hydrochloride is used as a reactant in chemical synthesis processes, where its amine and acetamide groups can participate in various chemical reactions to form a wide range of derivative compounds. This versatility in synthesis makes it a valuable intermediate in the preparation of complex organic molecules with potential applications in various fields, including pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 100-46-9 benzylamine 

Downstream Products

• 106653-07-0 N-(N-acetyl-α-aspartyl)-glycine benzylamide 
• 40847-11-8 N-Benzyloxycarbonyl-L-alanyl-glycinbenzylamid 
• 105310-97-2 N-benzyl-α-diazoacetamide 
• 43120-28-1 methyl 1H-indazole-3-carboxylate 
• 271-44-3 benzimidazole 
• 937396-37-7 3-benzyl-2,2-dimethylimidazolidin-4-one 
• 67863-06-3 2-benzyl-[1,2,5]thiadiazol-3-one 
• 103326-31-4 N-Triphenylmethyl-glycyl-glykolyl-glycin-(N-benzyl-amid) 
• 68876-15-3 2-benzyl-4-chloro-[1,2,5]thiadiazol-3-one 
• 68876-37-9 benzyl-[1,2,5]thiadiazol-3-yl-amine 
• 40847-10-7 N-CBz-Gly-Gly-NHBn 

Relevant academic research and scientific papers

NovelN-transfer reagent for converting α-amino acid derivatives to α-diazo compounds

A novel universalN-transfer reagent for direct and effective transformation of α-amino ketones, acetamides, and esters to the corresponding α-diazo products under mild basic conditions has been developed. This one-step synthetic approach not only allows for generation of α-substituted-α-diazo carbonyl compounds from α-amino acid derivatives but also permits preparation of α-diazo dipeptides fromN-terminal dipeptides (32 examples, up to 91%).

Direct cycle between co-product and reactant: An approach to improve the atom economy and its application in the synthesis and protection of primary amines

Two important goals of green chemistry are to maximize the efficiency of reactants and to minimize the production of waste. In this study, a novel approach to improve the atom economy of a chemical process was developed by incorporating a direct cycle between a co-product and a reactant of the same reaction. To demonstrate this concept, recoverable 3,4-diphenylmaleic anhydride (1) was designed and used for the atom-economical synthesis of aliphatic primary amines from aqueous ammonia. In each individual cycle, only ammonia and alkyl halide were consumed, and 1 was recovered in nearly a quantitative yield. In this approach for developing atom-economical protecting agents, 1 showed good performance as a recoverable protecting agent for primary amines. The broad substrate scope, good tolerance to various reaction conditions, and high reaction and recovery rates make 1 a valuable complement to conventional primary amine protecting agents.

Selective Reactions of Azide-Substituted α-Diazo Amides with Olefins and Alcohols Using Rhodium(II) Catalysts

The synthesis and addition of azide-substituted α-diazo amides such as N-(4-azidophenyl)-α-diazoacetamide and N-(4-azido-2-hydroxyphenyl)-α-diazoacetamide to olefins and alcohols using either rhodium(II) acetate or preferably rhodium(II) pivalate provided cyclopropanecarboxamides and α-alkoxy amides, respectively, without disrupting the azide functionality.These azide-bearing α-diazo amides are potentially useful in the preparation of photoaffinity cross-linking reagents for studying the mechanism of action of natural products.