204444-58-6

Basic information

• Product Name: 5-bromo-1-(4-iodophenacyl)-2-methyl-4-nitroimidazole
• CAS NO: 204444-58-6
• Molecular Weight: 450.03
• Mol File: 204444-58-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-bromo-1-(4-iodophenacyl)-2-methyl-4-nitroimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-1-(4-iodophenacyl)-2-methyl-4-nitroimidazole(204444-58-6)
• EPA Substance Registry System: 5-bromo-1-(4-iodophenacyl)-2-methyl-4-nitroimidazole(204444-58-6)

Safety Data

• Hazardous Substances Data: 204444-58-6(Hazardous Substances Data)

Upstream product

• 18874-52-7 4-bromo-2-methyl-5-nitroimidazole 
• 31827-94-8 2-bromo-1-(4-iodophenyl)ethanone 
• 18874-52-7 5-bromo-2-methyl-4-nitro-1H-imidazole 
• 204444-56-4 4-bromo-2-methyl-1-(2-iodoophenacyl)-5-nitroimidazole 

Relevant articles and documents

Tetrabutyl ammonium bromide as a catalyst for reaction of 5(4)-bromo-2-methyl-4(5)-nitroimidazole with phenacyl bromides

Reactions of 5(4)-bromo-2-methyl-4(5)-nitroimidazole with phenacyl bromide, tetrabutylammonium bromide (TBAB) and sodium bicarbonate in the sonication condition resulted in a mixture of 4-bromo-5-nitroimidazoles [IIIa-e] and 5-bromo-4-nitroimidazoles [IVa-e] at an excellent yield of over 85% and, surprisingly, at the isomers ratio of 2:1.

Synthesis of some 5-amino-2-methyl-4-nitro-1-phenacylimidazoles

Reaction of 4(5)-bromo-2-methyl-5(4)-nitroimidazole with phenacyl bromide derivatives gave two isomers: 4-bromo-5-nitroimidazoles (4a-e) and 5-bromo-4-nitroimidazoles (5a-e). Compounds 5a-e were treated with cyclic secondary amines to afford expected 5-amino-4-nitroimidazole derivatives 6a-c - 10a-b.