204458-72-0

Upstream product

• 103-40-2 succinic acid monobenzyl ester 
• 236743-92-3 (R)-1-(O-benzyl-N-tert-butoxycarbonyl-L-threonine)-2-(2-phenethoxy)-3-(tri-O-benzyl-α-L-fucopyranosyl)propane 
• 236743-68-3 (R)-1-azido-2-(2-phenethoxy)-3-(tri-O-benzyl-α-L-fucopyranosyl)propane 
• 236743-81-0 (R)-2-(2-phenethoxy)-3-(tri-O-benzyl-α-L-fucopyranosyl)-1-propyl amine 
• 236743-54-7 (R)-1-azido-3-(tri-O-benzyl-α-L-fucopyranosyl)-2-propanol 
• 236743-51-4 1,2-epoxy-3-(tri-O-benzyl-α-L-fucopyranosyl)-propane 
• 167990-42-3 3-(2,3,4-tri-O-benzyl-α-L-fucopyranosyl)-1-propene 
• 15260-10-3 N-Boc-O-benzyl-L-threonine 

Relevant academic research and scientific papers

Design, synthesis and biological evaluation of aryl-substituted sialyl Lewis X mimetics prepared via cross-metathesis of C-fucopeptides

Several aryl substituted C-fucopeptides have been developed as sialyl Lewis X mimetics. Although the compounds have a much simpler structure compared to SLe(x), up to 3-times higher binding affinity toward E-selectin and >1000 times toward P-selectin was observed. Furthermore, a convenient strategy for generating a number of analogues from a SLe(x) mimetic template at a very late stage of the synthesis was introduced, using a ruthenium catalyzed cross olefin metathesis under benchtop conditions. Copyright (C) 1999 Elsevier Science Ltd.