204458-77-5

Upstream product

• 103-40-2 succinic acid monobenzyl ester 
• 4392-24-9 Cinnamyl bromide 
• 174713-20-3 (2S,3R)-2-amino-4-benzyloxy-N-(tert-butoxycarbonyl)-3-hydroxybutyric acid 
• 236744-25-5 {(1S,2R)-3-Benzyloxy-2-hydroxy-1-[(S)-2-(3-phenyl-propoxy)-3-((2S,3R,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yl)-propylcarbamoyl]-propyl}-carbamic acid tert-butyl ester 
• 236744-19-7 (S)-N-(tert-butoxycarbonyl)-2-(3-phenyl-2-phenoxy)-3-(tri-O-benzyl-α-L-fucopyranosyl)-1-propyl amine 

Relevant academic research and scientific papers

Design, synthesis and biological evaluation of aryl-substituted sialyl Lewis X mimetics prepared via cross-metathesis of C-fucopeptides

Several aryl substituted C-fucopeptides have been developed as sialyl Lewis X mimetics. Although the compounds have a much simpler structure compared to SLe(x), up to 3-times higher binding affinity toward E-selectin and >1000 times toward P-selectin was observed. Furthermore, a convenient strategy for generating a number of analogues from a SLe(x) mimetic template at a very late stage of the synthesis was introduced, using a ruthenium catalyzed cross olefin metathesis under benchtop conditions. Copyright (C) 1999 Elsevier Science Ltd.