204512-54-9

Upstream product

• 506-59-2 N,N-dimethylammonium chloride 
• 204512-52-7 5-(4-fluorophenyl)-4-[4-(methylthio)phenyl]thiophene-2-carboxylic acid 
• 204512-50-5 (Z)-3-Chloro-3-(4-fluoro-phenyl)-2-(4-methylsulfanyl-phenyl)-propenal 
• 36187-57-2 1-(4-fluorophenyl)-2-(4-(methylthio)phenyl)ethanone 

Downstream Products

• 140403-62-9 N,N-dimethyl-5-(4-fluorophenyl)-4-[4-(methylthio)phenyl]-2-thenylamine 

Relevant academic research and scientific papers

Studies on anti-inflammatory agents. VI. Synthesis and pharmacological properties of 2,3-diarylthiophenes

A series of novel 5-substituted-2,3-diarylthiophenes has been synthesized and found to be active in the rat adjuvant arthritis (AA) model and/or in the yeast-induced hyperalgesia (Randall-Selitto) assay. Among the compounds synthesized herein, 2-(4-fluorophenyl)-3-[4- (methylsulfonyl)phenyl]-S-(trifluoromethyl)thiophene (6a) exhibited the most potent activities on AA, collagen-Induced arthritis (CIA) and the delayed- type hypersensitivity response to type II collagen. 5-Bromo-2-[4- (methylamino)phenyl]-3-[4-(methylsulfinyl)phenyl]thiophene (38) is also a potent inhibitor of AA, CIA, hyperalgesia and in vitro tumor necrosis factor- α production.

Thiophene derivatives

This invention relates to new thiophene derivatives having antiinflammatory and analgesic activities and represented by the general formula [I]: STR1 wherein R1 is hydrogen, halogen, cyano, substituted lower alkyl, substituted or unsubstituted