204513-62-2

Basic information

• Product Name: 4-bromo-2-(methylthio)thiazole
• Synonyms: 4-bromo-2-(methylthio)thiazole;4-Bromo-2-(methylsulphanyl)-1,3-thiazole
• CAS NO: 204513-62-2
• Molecular Formula: C₄H₄BrNS₂
• Molecular Weight: 210.119
• Mol File: 204513-62-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 279.3°C at 760 mmHg
• Flash Point: 122.7°C
• Appearance: /
• Density: 1.81g/cm³
• Vapor Pressure: 0.00688mmHg at 25°C
• Refractive Index: 1.664
• PKA: -0.35±0.10(Predicted)
• CAS DataBase Reference: 4-bromo-2-(methylthio)thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-2-(methylthio)thiazole(204513-62-2)
• EPA Substance Registry System: 4-bromo-2-(methylthio)thiazole(204513-62-2)

Safety Data

• Statements: 43
• Safety Statements: 36/37
• Hazardous Substances Data: 204513-62-2(Hazardous Substances Data)

Usage

General Description

4-bromo-2-(methylthio)thiazole is a chemical compound with the molecular formula C5H6BrNS2. It is a thiazole derivative, containing a bromine atom and a methylthio group. This chemical is commonly used in organic synthesis and functional group transformation reactions. It is also utilized in the pharmaceutical industry as a building block for the synthesis of potential drug candidates. The compound has a distinct odor and is known to be a potential irritant to the skin, eyes, and respiratory system. Additionally, it has been found to possess antimicrobial and antifungal properties, making it a valuable compound in the field of medicinal and agricultural chemistry.

InChI:InChI=1/C4H4BrNS2/c1-7-4-6-3(5)2-8-4/h2H,1H3

Upstream product

• 4175-77-3 2,4-dibromo-1,3-thiazole 
• 5188-07-8 sodium thiomethoxide 

Downstream Products

• 41029-86-1 2-Methylthio-4-formylthiazol 
• 2103-93-7 2-methylmercapto-4-(4'-bromophenyl)thiazole 

Relevant articles and documents

Small-molecule anticancer agents kill cancer cells by harnessing reactive oxygen species in an iron-dependent manner

In the course of generating a library of open-chain epothilones, we discovered a new class of small molecule anticancer agents that has no effect on tubulin but instead kills selected cancer cell lines by harnessing reactive oxygen species in an iron-dependent manner. Results of the preliminary studies are consistent with the recently described cell death mechanism ferroptosis. Studies are in progress to confirm ferroptosis as the cell death mechanism and to identify the specific molecular targets of these small molecule anticancer agents.

EPOTHILONE ANALOGS, METHODS OF SYNTHESIS, METHODS OF TREATMENT, AND DRUG CONJUGATES THEREOF

In one aspect, the present disclosure provides epothilone analogs of the formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.

Total synthesis of Epothilone E and related side-chain modified analogues via a stille coupling based strategy

A Stille coupling strategy has been utilized to complete a total synthesis of epothilone E from vinyl iodide 7 and thiazole-stannane 8h. The central core fragment 7 and its trans-isomer 11 were prepared from triene 15 using ring-closing metathesis (RCM),