204515-22-0Relevant academic research and scientific papers
An economical synthesis of famciclovir
Hijiya, Toyoto,Yamashita, Keizo,Kojima, Mitsuhiko,Uchida, Yumiko,Katayama, Satoshi,Torii, Takayoshi,Shiragami, Hiroshi,Izawa, Kunisuke
, p. 653 - 654 (1999)
An economical synthesis of famciclovir from N-2-acetyl-7-benzylguanine by a novel regioselective alkylation with the diester cyclopropane compound was developed.
Improved industrial syntheses of penciclovir and famciclovir using N2-acetyl-7-benzylguanine and a cyclic side chain precursor
Torii, Takayoshi,Yamashita, Keizo,Kojima, Mitsuhiko,Suzuki, Yumiko,Hijiya, Toyoto,Izawa, Kunisuke
, p. 625 - 634 (2006)
We have established practical synthetic methods for penciclovir (PCV, 1) and famciclovir (FCV, 2) from N2-acetyl-7-benzylguanine (NAc7BnG, 3) and 6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione (4)-the latter being a more easily prepared cyclic precursor
